Synapses and circuits in the brain are responsible for who we are and how we perceive the world around us. Our lab explores the fundamental features shaping the strength of synaptic transmission in the brain. Current work targets the central synaptic pathways involved in the processing of smell. We use electrophysiological and optical recording techniques to study the properties of olfactory circuits in brain slices and in vivo. Ultimately, we hope to to reveal how circuits process and encode sensory information.
Poo, C and Isaacson, J.S. (2007). An early critical period for long-term plasticity and structural modification of sensory synapses in olfactory cortex. Journal of Neuroscience, 27:7553-8, 2007.
Franks, K.M. and Isaacson, J.S. (2006). Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding. Neuron, 49:357-63.
Franks, K. M., and Isaacson, J. S. (2005). Synapse specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. Neuron, 7: 101-14.
Murphy, G. J., Darcy, D. P., and Isaacson, J. S. (2005). Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit. Nature Neuroscience 8, 354-364.
Cang, J. and Isaacson, J.S. (2003). In vivo whole-cell recording of odor-evoked synaptic transmission in the rat olfactory bulb. J. Neurosci, 23:4108-16.