Central nervous system (CNS) morphology, protein localization, imaging of neurons and their processes, and neuroinformatics.
As co-director of the National Center for Microscopy and Imaging Research, Dr. Martone has been leading the development of databases for light and electron microscopic data and new techniques and software tools to acquire and represent this knowledge within realistic neuronal models. She was a major contributor in the creation of the Cell-Centered Database, one of the first Internet databases for cell-level structural data. Her defining work on the CCDB and neuroinformatics in general has brought the Martone group international recognition.
As a member of the leadership team of the Biomedical Informatics Research Network project integrating high speed networks and distributed high-performance computing for fostering large-scale collaborations in biomedical science, Dr. Martone serves as the scientific coordinator of the Mouse BIRN test bed. One of several research projects driving the development of BIRN, the Mouse BIRN test bed is dedicated to developing methods for multiscale investigations of mouse models of human neurological disease. Dr. Martone is the co-chair of BIRN’s Ontology Task Force, tasked with advancing database interoperability across each of BIRN databases by establishing a common lexicon to share knowledge sources.
Dr. Martone’s recent work has focused on building an ontology for describing the subcellular anatomy of the nervous system, and integrating the ontology into image analysis and data mining tools. Dr. Martone is a co-principal investigator in the newly awarded NIH contract to create a Neuroinformatics Framework, a national pilot project awarded to establish terminology standards for neuroscience. This work is expected to advance how neuroscientists perform concept-based queries. Dr. Martone also serves as a member of the Neuroinformatics Committee for the Society for Neurosciences.
Dr. Martone’s scientific efforts have resulted in an extensive publication record and her teaching activities include both formal and individual coursework. She shares responsibility in teaching Introduction to Light and Electron Microscopy (NEU259),Workshop in Light and Electron Microscopy (NEU260/BIOENG260), and Mammalian Neuroanatomy (NEU256).
Martone ME, Tran J, Wong WW, Sargis J, Fong L, Larson S, Lamont SP, Gupta A and Ellisman MH (2008) The Cell Centered Database project: An update on building community resources for managing and sharing 3D imaging data. J Struct Biol 161(3):220-231.
Larson SD, Fong LL, Gupta A, Condit C, Bug WJ and Martone ME (2007) A Formal Ontology for Subcellular Anatomy. Frontiers in Neuroinformatics 1(3).
Martone ME, Gupta A and Ellisman MH (2004) E-neuroscience: challenges and triumphs in integrating distributed data from molecules to brains. Nat Neurosci 7(5):467-472.
Bushong EA, Martone ME and Ellisman MH (2003) Examination of the relationship between astrocyte morphology and laminar boundaries in the molecular layer of adult dentate gyrus. J Comp Neurol 462(2):241-251.