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Dr. John Chang

John Chang

Dr. John Chang studies the cellular and molecular mechanisms underlying T lymphocyte fate specification.  Dr. Chang is the recipient of several awards, including the HHMI Physician-Scientist Early Career Award and the NIH Director's New Innovator Award, and is currently funded by the several grants from the National Institutes of Health.

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About the Lab

A central problem faced by multi-cellular organisms is the need for rare progenitor cells to continually produce terminally differentiated cells while also preserving a self-renewing lineage.  In the mammalian immune system, T lymphocytes face a similar need for simultaneous differentiation and regeneration.  The goal of our research is to understand what mechanisms allow a progenitor cell to give rise to two daughter cells that adopt such different fates, using the T lymphocyte as a model system.

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Contact Us

Lab Location
University of California, San Diego
Biomedical Research Facility 2 (BRF2)
Room 5220L

Mailing Address
University of California, San Diego
9500 Gilman Drive #0063
La Jolla, CA 92093-0063

Phone: 858-822-7568
Fax: 858-822-7652


Congratulations to Daniel Garcia and Jane Klann for winning Best Retreat Poster Awards at the 2015 Biomedical Sciences Retreat!

Congratulations to Brigid Boland for receiving a Crohn's and Colitis Foundation of America Career Development Award!

In press: Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8+ T Lymphocyte Fates. Congratulations to Pat Metz!

In press: Downregulation of 26S Proteasome Catalytic Activity Promotes Epithelial Mesenchymal Transition. Highlighted by UCSD Health Sciences. Congratulations to Asoka Banno and Daniel Garcia!