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Dr. John Chang

John Chang

Dr. John Chang studies the cellular and molecular mechanisms underlying T lymphocyte fate specification.  Dr. Chang is the recipient of several awards, including the HHMI Physician-Scientist Early Career Award and the NIH Director's New Innovator Award, and is currently funded by the several grants from the National Institutes of Health and the Crohn's and Colitis Foundation of America. In 2016, Dr. Chang was elected to the American Society of Clinical Investigation and received the AGA-GRG Young Investigator Award in Basic Science.

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About the Lab

A central problem faced by multi-cellular organisms is the need for rare progenitor cells to continually produce terminally differentiated cells while also preserving a self-renewing lineage.  In the mammalian immune system, T lymphocytes face a similar need for simultaneous differentiation and regeneration.  The goal of our research is to understand the molecular mechanisms enabling activated T lymphocytes to give rise to differentially fated progeny.

More about our lab's research >

Contact Us

Lab Location
University of California, San Diego
Biomedical Research Facility 2 (BRF2)
Room 5220L

Mailing Address
University of California, San Diego
9500 Gilman Drive #0063
La Jolla, CA 92093-0063

Phone: 858-822-7568
Fax: 858-822-7652

Spotlight

Congratulations to Daniel Garcia and Jane Klann for winning Best Retreat Poster Awards at the 2015 Biomedical Sciences Retreat!

Congratulations to Brigid Boland for receiving a Crohn's and Colitis Foundation of America Career Development Award!

Congratulations to Jane Klann and Christella Widjaja for receiving AAI Trainee Abstract Awards!

In press: Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8+ T Lymphocyte Fates. Congratulations to Pat Metz!

In press: Downregulation of 26S Proteasome Catalytic Activity Promotes Epithelial Mesenchymal Transition. Highlighted by UCSD Health Sciences. Congratulations to Asoka Banno and Daniel Garcia!

In press: The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. Highlighted by Journal of Immunology "In this Issue". Congratulations to Soo Ngoi!