Dr. Dale is founding Co-Director of the Multimodal Imaging Laboratory, an interdisciplinary initiative of the Departments of Neurosciences and Radiology. He is highly skilled in the development and utilization of multimodality imaging technologies.
Within both departments, Dr. Dale is the designated point person for integrating the various modes and methods of collecting imaging data, including functional MRI (fMRI), magnetoencephalography (MEG), electroencephalography (EEG), and optical imaging. His efforts are directed in three areas: continuing development and refinement of accurate and automated algorithms for evaluation subjects using multimodality approaches to data collection; statistical analysis of data; and conducting studies in animal models using optical imaging, high field fMRI, and electrophysiological recordings to enhance the interpretation of neuroimaging studies.
Correct modeling of EEG/MEG and optical signals requires an accurate segmentation of the tissues within the head. A major component of Dr. Dale's laboratory effort has been on developing accurate and automated algorithms for head segmentation. This work began while he was a graduate student at UCSD and continued with Dr. Bruce Fischl and Dr. Eric Halgren at Harvard Medical School. Efforts to date have resulted in the development of software tools that enable the automated segmentation of the entire head and brain, including the neocortex and subcortical structures, from MRI data. As Dr. Dale notes, "The task of automated structure segmentation of human brain anatomy has been a Holy Grail for years."
Investigators at the Multimodal Imaging Lab are currently involved in several clinical research studies, applying these methods to assessment of regional morphometric changes associated with normal and abnormal development, aging, and brain-related diseases such as schizophrenia, Alzheimer's disease, and Huntington's disease.
Halgren E, Sherfey J, Irimia A, Dale AM, Marinkovic K. Sequential temporo-fronto-temporal activation during monitoring of the auditory environment for temporal patterns. Hum Brain Mapp. 2010 Jul 27.
McEvoy LK, Edland SD, Holland D, Hagler DJ Jr, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer JB, Dale AM; Alzheimers Disease Neuroimaging Initiative. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):269-77. PubMed PMID: 20683184; PubMed Central PMCID: PMC2929320.
Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Blennow K, Brewer JB, Dale AM; Alzheimer's Disease Neuroimaging Initiative. Brain atrophy in healthy aging is related to CSF levels of Abeta1-42. Cereb Cortex. 2010 Sep;20(9):2069-79. Epub 2010 Jan 4. PubMed PMID: 20051356.
Panizzon MS, Hauger R, Dale AM, Eaves LJ, Eyler LT, Fischl B, Fennema-Notestine C, Franz CE, Grant MD, Jak AJ, Jacobson KC, Lyons MJ, Mendoza SP, Neale MC, Prom-Wormley EC, Seidman LJ, Tsuang MT, Xian H, Kremen WS. Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology. 2010 Sep 7;75(10):874-80. PubMed PMID: 20819998.
Brown TT, Kuperman JM, Erhart M, White NS, Roddey JC, Shankaranarayanan A, Han ET, Rettmann D, Dale AM. Prospective motion correction of high-resolution magnetic resonance imaging data in children. Neuroimage. 2010 Oct 15;53(1):139-45. Epub 2010 Jun 11. PubMed PMID: 20542120.
Destrieux C, Fischl B, Dale A, Halgren E. Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. Neuroimage. 2010 Oct 15;53(1):1-15. Epub 2010 Jun 12. PubMed PMID: 20547229; PubMed Central PMCID: PMC2937159.
McDonald CR, Thesen T, Carlson C, Blumberg M, Girard HM, Trongnetrpunya A, Sherfey JS, Devinsky O, Kuzniecky R, Dolye WK, Cash SS, Leonard MK, Hagler DJ Jr, Dale AM, Halgren E. Multimodal imaging of repetition priming: Using fMRI, MEG, and intracranial EEG to reveal spatiotemporal profiles of word processing. Neuroimage. 2010 Nov 1;53(2):707-17. Epub 2010 Jul 8. PubMed PMID: 20620212; PubMed Central PMCID: PMC2930128.
Kremen WS, O'Brien RC, Panizzon MS, Prom-Wormley E, Eaves LJ, Eisen SA, Eyler LT, Hauger RL, Fennema-Notestine C, Fischl B, Grant MD, Hellhammer DH, Jak AJ, Jacobson KC, Jernigan TL, Lupien SJ, Lyons MJ, Mendoza SP, Neale MC, Seidman LJ, Thermenos HW, Tsuang MT, Dale AM, Franz CE. Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study. Neuroimage. 2010 Nov 15;53(3):1093-102. Epub 2010 Feb 13. PubMed PMID: 20156572.
Murphy EA, Holland D, Donohue M, McEvoy LK, Hagler DJ Jr, Dale AM, Brewer JB; Alzheimer's Disease Neuroimaging Initiative. Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls. Neuroimage. 2010 Dec;53(4):1310-7. Epub 2010 Jul 13. PubMed PMID: 20633660; PubMed Central PMCID: PMC2939234.
McDonald CR, Hagler DJ Jr, Girard HM, Pung C, Ahmadi ME, Holland D, Patel RH, Barba D, Tecoma ES, Iragui VJ, Halgren E, Dale AM. Changes in fiber tract integrity and visual fields after anterior temporal lobectomy. Neurology. 2010 Sep 29. [Epub ahead of print] PubMed PMID: 20881271.