David Bredt, MD, PhD

Contact Information

Email: dbredt@its.jnj.com
Phone: 858.320.3374

Mailing Address:

Janssen Pharmaceutical Companies of Johnson and Johnson
3210 Merryfield Row
San Diego, CA 92121


Pharmacology of glutamate receptors

Horresh I, Poliak S, Grant S, Bredt D, Rasband MN, Peles E. Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J Neurosci. 2008 28:14213-22

Kato AS, Siuda ER, Nisenbaum ES, Bredt DS. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Neuron. 2008 59:986-96

Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol. 2009 186:147-60.

Kato AS, Gill MB, Yu H, Nisenbaum ES, and Bredt DS TARPs differentially decorate AMPA receptors to specify neuropharmacology Trends in Neuroscience 2010 33:241-8

Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, QianY-W, Nisenbaum ES, Tomita S, Bredt DS Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins Neuron 2010 68:1082-96.

Ivanova S, Gregorc U, Vidergar N, Javier R, Bredt DS, Vandenabeele P, Pardo J, Simon MM, Turk V, Banks L, Turk B. MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis. Cell Death Dis. 2011 2:e116.

Schober DA, Gill MB, Yu H, Gernert DL, Jeffries MW, Ornstein PL, Kato AS, Felder CC, Bredt DS. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. J Biol Chem. 2011 286: 13134-42.

Gill MB, Bredt DS An emerging role for TARPs in neuropsychiatric disorders. Neuropsychopharmacology 2011 36: 62-3.

Gill MB, Kato AS, Roberts MF, Yu H, Wang H, Tomita S, Bredt DS Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. Journal of Neuroscience 2011 ;31:6928-38.

Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S. PDZ binding of TARP?-8 controls synaptic transmission but not synaptic plasticity. Nature Neuroscience 2011 14:1410-2

Gill MB, Kato AS, Wang H, Bredt DS AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. European Journal of Neuroscience. 2012 Jan;35(2):182-94

Fukata Y, Bredt DS, Fukata M. Protein Palmitoylation by DHHC Protein Family. In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press Chapter

Gill MB, Kato AS, Yu H, Tomita S, Bredt DS. Cornichon-2 controls assembly of TARP-containing AMPA receptors The Journal of Neuroscience 2011 (in press)