Nigel Calcutt, PhD

Nigel Calcutt, PhD

Professor
Department of Pathology

Contact Information

Email: ncalcutt@ucsd.edu
Phone: 858.534.5331
Lab Phone: 858.534.3309

Location:
Biomedical Sciences Building, Room 2048A

Mailing Address:
University of California, San Diego
9500 Gilman Drive #0612
La Jolla, CA 92093

Research Title
Peripheral Neuropathies

Research Description
My research is focused on mechanisms of peripheral nerve disease and the identification of new therapeutic approaches to prevent onset of neuropathy or alleviate symptoms of an existing neuropathy such as sensory loss or pain. Most students and Fellows in my laboratory work on cellular and animal models of diabetic neuropathy although we also have projects looking at the toxic neuropathies that are side effects of certain cancer drugs and at models of HIV-associated peripheral neuropathy. We have adopted a multi-disciplinary approach to addressing the etiology of diabetic neuropathy and apply a diverse array of techniques that range from molecular and biochemical investigations of fundamental disease mechanisms to physiologic and behavioral assessments of nerve function and the efficacy of potential therapeutic strategies. We also collaborate with a number of biotechnology and pharmaceutical companies, so that the etiologic mechanisms that we propose can be tested by rational drug design and in vivo pharmacology and ultimately by clinical trials. Students wishing to work in my laboratory must have a sense of adventure, want to appreciate the full spectrum of a disease process and be flexible enough to answer research questions by application of a range of experimental techniques.

Lee-Kubli, CA, Calcutt NA (2014) Altered rate dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain. Pain 155:250-260.

Hedstrom KL, Murtie JC, Albers K, Calcutt NA, Corfas G. (2014) Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRa/RET receptor signaling. Proc Natl Acad Sci U S A. 111:2325-2330.

Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt NA (2013) Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J. Peripher. Nerv. Syst. 18:306-315

Calcutt NA (2013) Location, location, location: is the pain of diabetic neuropathy generated by hyperactive sensory neurons? Diabetes 62:3658-3660.

Jolivalt, CG, Lee, CA, Ramos, KM, Calcutt, NA (2008) Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium chloride co-transporters. Pain 140:48-57. NIHMSID 78967

Malisza KL, Jones C, Gruwel, ML, Foreman D, Fernyhough P, Calcutt NA (2009) Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. JMRI 30: 271-276. PMC2742673

Calcutt NA, Cooper ME, Kern TS, Schmidt AM (2009) Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nature Rev. Drug Discov. 8:417-429. PMID 19404313

Fernyhough P, Calcutt NA (2010) Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium 47:130-139.

Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA. (2011) GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. Diabetes Obes Metab 13:990-1000 PMC3177968