Subhojit Roy

 

 

Contact Information


The Roy lab's main interest is to explore mechanisms that convey and deposit cargoes into axons, dendrites and synapses. Towards this, they are broadly interested in physiologic neuronal transport/trafficking, and also potential abnormalities in these processes in neurodegenerative diseases like Alzheimer's and Parkinson's disease. Techniques used: Live imaging of neuronal trafficking using regular and photoactivatable fluorescent proteins, image-analysis, immunofluorescence, biochemistry, proteomics/bioinformatics (in collaboration with John Yates, Scripps) and data-driven computational modeling.

For more details and updated information, please visit http://www.roylab.org

Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid-beta protein oligomers. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S*. Traffic, Feb 6 2012 online

A simple photoactivation and image-analysis module for visualizing and analyzing axonal transport with high temporal resolution. Roy S*, Yang Ge, Tang Y and Scott D. Nature Protocols, 2011 Dec 15;7(1):62-8

Mechanistic logic underlying the axonal transport of cytosolic proteins. Scott D, Das U, Tang Y and Roy S*. Neuron May 2011 12;70(3):441-54.

A pathologic cascade leading to synaptic dysfunction in รก-synuclein-induced neurodegeneration (2010). Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S*. Journal of Neuroscience Jun 2010 16;30(24):8083-95.