Pilot Grant Awardees

​​​​​​​​​​​​​​​C3 / Pedal the Cause

2015

$75K/year 

Project 1
“Targeting KRAS Mutant lung cancer with biphosphonated/statins and rapamycin analogs”
Lyudmila Bazhenova, MD (Moores Cancer Center at UC San Diego Health)​
Inder Verma, PhD (Salk Institute Cancer Center)
Abstract


Project 2
“The GNAS-PKA Onco-Signaling Network in Colorectal Malignancies”
Silvio Gutkind, PhD (Moores Cancer Center at UC San Diego Health)
Susan Taylor, PhD (Moores Cancer Center at UC San Diego Health)
Tony Hunter, PhD (Salk Institute Cancer Center)

Project 3
“Epigenetic Basis of Platinum Drug-resistance in Ovarian Cancer”
Olivier Harismendy, PhD (Moores Cancer Center at UC San Diego Health)
Stephen Howell, MD (Moores Cancer Center at UC San Diego Health)
Joseph Ecker, PhD (Salk Institute Cancer Center)

Project 4
“KRAS Addiction and Protein Biomarkers of Response to Anti-KRAS Therapy in NSCLC Patient-derived Xenografts”
Hatim Husain, MD (Moores Cancer Center at UC San Diego Health)
Garth Powis, DPhil (Sanford Burnham Prebys Cancer Center)

Project 5
“Mechanisms Linking Prolonged Nightly Fasting with Cancer Risk”
Ruth Patterson, PhD (Moores Cancer Center at UC San Diego Health)
Dorothy Sears, PhD (Moores Cancer Center at UC San Diego Health)
Satchidananda Panda, PhD (Salk Institute Cancer Center)

Project 6
“Targeting Stem Cell Signals in Cancer Development & Progression”
Tannishtha Reya, PhD (Moores Cancer Center at UC San Diego Health)
Michael Jackson, PhD (Sanford Burnham Prebys Cancer Center)

Project 7
“Detecting Correlates of Vaccine Responses in Allogeneic Hematopoietic Stem Cell Transplant Recipients”
Randy Taplitz, PhD (Moores Cancer Center at UC San Diego Health)
Shane Crotty, PhD (La Jolla Institute for Allergy and Immunology)​
Abstract
​​

2014

Project 1
“Highly selective, synthetic, cleavage specificity-based nanobiosensors for tumorigenic and anti-tumorigenic MMPs”
$75K/year
Alex Strongin, PhD (Sanford Burnham Prebys)
Shu Chien, MD, PhD (Moores Cancer Center)
Peter Yingxiao Wang, PhD (Moores Cancer Center)
Abstract

Project 2
“Cytotoxic breast cancer treatment effects on aging”
$75K/year
Deborah Kado, MD, MS (Moores Cancer Center)
Jan Karlseder, PhD (Salk)
Abstract

Project 3
“In vivo modeling of anti-tumor responses of human melanoma patients and their responses to checkpoint immunotherapy”
$75K/year
Linda Bradley, PhD (Sanford Burnham Prebys)
Greg Daniels, MD, PhD (Moores Cancer Center)
Abstract

Team Science Award
“Therapeutic reprogramming of pancreatic cancer stroma via modulation of p62 and p53”
$300K/2 years
Andrew Lowy, MD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk)
Cosimo Commisso, PhD (Sanford Burnham Prebys)
Jorge Moscat, PhD (Sanford Burnham Prebys)
Abstract

2013

$75K/year

Project 1
“Small molecule screen for inhibitors of the GOLPH3 pathway”
Seth Field, MD, PhD (Moores Cancer Center)
Michael Jackson, PhD (Sanford Burnham Prebys)
Abstract 

Project 2
“Applying p38 MAPK inhibitors to tackle breast cancer metastasis”
Michael Karin, PhD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk) 
Abstract

Project 3
“Stromal reprogramming to enhance the effectiveness of pancreatic cancer therapy”
Andrew Lowy, MD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk) 
Abstract

Project 4
“Targeting imatinib-resistant, KIT-negative cells in human GISTs”
Jason K. Sicklick, MD (Moores Cancer Center)
Robert J. Wechsler-Reya, PhD (Sanford Burnham Prebys)
Abstract 

Project 5
“Demonstrating the clinical utility of whole exome sequencing for cancer patients”
Lisa Madlensky, PhD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk)
Abstract

American Cancer Society-Institutional Research Grants (ACS-IRG)

2015

$30K/year

"Photoacoustic Molecular Imaging of Ovarian Cancer"
Jesse Jokerst, PhD
Abstract

"Global Profiling of Extracellular Protease Activity from Lung Cancer Cells"
Anthony O'Donoghue, PhD
Abstract

"Restriction Spectrum Imaging for Presurgical Assessment of Neoadjuvant Treatment Response in Rectal Cancer"
Daniel Simpson, MD
Abstract

"The Role of Differential mRNA Localization in the Stress Adaption of Cancer Cells"
Brian Zid, PhD
Abstract

"Factors affecting Parental Satisfaction, Anxiety and Comprehension of Informed Consent in Pedatric Oncology Clinical Trials"
Paula Aristizabal, MD, MAS
Abstract

2014

$30K/year 

“Factors affecting parental satisfaction, anxiety and comprehension of the informed consent in pediatric oncology clinical trial” 
Paula Aristizabal, MD
Abstract

“Integrin αvβ3 drives an EMT-independent role for slug in cancer stemness” 
Jay Desgrosellier, PhD
Abstract

“Prospective metabolite biomarkers of human breast cancer” 
Mohit Jain, MD, PhD
Abstract 

“The role of misregulated epigenetic mechanisms in cellular transformation and colorectal carcinoma”
Shannon Lauberth, PhD
Abstract

“The cost-effectiveness of using nicotine replacement therapy and financial incentives to promote utilization of smokers’ quitlines and smoking cessation among Asian-language speakers: a randomized, controlled pilot trial” 
Yuyan Shi, PhD
Abstract

“Utilizing FRET biosensors to optimize the targeting efficacy of CAR-based T-cell immunotherapy for individual B-ALL patients”
Xiandong Xu, MD, PhD
Abstract

2013

$30K/year 

“Translational bioinformatics of the NCI 60 proteome” 
Nuno Bandeira, PhD
Abstract

“Ultra-sensitive protein detection for early cancer diagnostics using magnetic tunnel junction (MTJ) biosensors” 
Drew Hall, PhD
Abstract

“Quantitative neuroimaging and neurocognitive assessment to measure radiation-induced brain injury in non-targeted tissue: implications for cognitive preservation” 
Jona Hattangadi-Gluth, MD
Abstract

“The role of misregulated epigenetic mechanisms in cellular transformation and colorectal carcinoma” 
Shannon Lauberth, PhD
Abstract

“Counterfeit Avastin health policy and legal analysis to improve cancer patient safety and public health”
Timothy Mackey, PhD
Abstract

Cancer Center Support Grant (CCSG)

201​6

$50K/year 

“Harnessing the full potential of novel immune therapies for oral cancer prevention and treatment” 
Silvio Gutkind, PhD and Ezra Cohen, MD
Abstract

“Therapeutic and Prognostic Potential of a Novel Signaling Pathway in Colorectal Cancer” 
Pradipta Ghosh, MD and Samuel Ho, MD
Abstract

“IND enabling studies of LT-415 a novel chemotherapeutic agent with a unique target” 
William Fenical, PhD and Stephen Howell, MD
Abstract​

2016 Breath of Hope Pilot Grant

“Monitoring the Dynamics of Early Tumor Response to Therapy by Detecting Circulating Tumor DNA in Blood and Urine” 
Hatim Husain, MD
Abstract​

2014

$50K/year 

“Copper PET imaging as a biomarker for prediction of response to cisplatin” 
Stephen Howell, MD, and David Vera, PhD
Abstract

“Imaging the metastatic potential of single tumor cells in lung adenocarcinoma” 
Pradipta Ghosh, MD, and Hatim Husain, MD
Abstract

“Prospective evaluation of restriction spectrum imaging in head and neck carcinoma” 
Quyen Nguyen, MD, PhD, and Anders Dale, PhD
Abstract

“Restriction spectrum imaging as a biomarker for monitoring disease progression and early response to therapy in patients with high-grade glioma” 
Carrie McDonald, PhD, and Jona Hattangadi-Gluth, MD
Abstract

“Development of theranostic antibody targeted delivery of radio sensitizers”
 Sunil Advani, MD, and Roger Tsien, PhD 
Abstract

Cancer Imaging Program (CIP)

2015

$20K/year 

“Abbreviated MRI vs. standard ultrasonography for hepatocellular carcinoma Surveillance in cirrhosis.” 
Claude Sirlin, MD, and Yuko Kono, MD, PhD
Abstract

“An integrative approach to histological sections – accelerating the integration of multi-modality imaging into clinical practice.” 
Hauke Bartsch, PhD, and David Hall, PhD
Abstract

“Preliminary evaluation of RSI MRI for whole body cancer detection.” 
David Karow, MD, PhD, J. Michael Randall, MD, and Joshua Kuperman, PhD
Abstract 

“Opto-acoustic imaging of a receptor-targeted contrast agent for detection of aggressive breast cancer.” 
David Vera, PhD, and Anne Wallace, MD
Abstract

“Enzyme-directed assembly of particle diagnostics for guided surgical resection of tumors.” 
Nathan Gianneschi, PhD, and Quyen Nguyen, MD, PhD
Abstract

“Radiation sparing of eloquent cortex in brain tumor patients using advanced quantitative neuroimaging and knowledge-based planning.”
Jona Hattangadi-Gluth, MD, and Kevin Moore, PhD
Abstract