My current and future research interests are directed in three different fronts. One aspect of my work is to use molecular, cellular, and whole animal approaches to understand physiology/pathophysiology of chronic pain in different pain systems. My laboratory utilizes a combination of in vitro and in vivo techniques to study the mechanisms behind neuropathic pain, complex regional pain syndrome, and diabetic neuropathy. My second area of focus is studying the effects of general and local anesthetics in modulating host immunity to various viral and bacterial infections. My emphasis as a clinician scientist is to translate findings in the basic science to effective therapy that can be applied in clinical trials and eventually be used in patients. To this end, the third area of focus is nanomedicine (application of nanotechnology within a field of medicine) focusing on developing new diagnostic and therapeutic platforms for various chronic pain states.
Doxorubicin conjugated quantum dots to target alveolar macrophages/inflammation. Chakravarthy KV, Davidson BA, Helinski JD, Ding H, Law WC, Yong KT, Prasad PN, Knight PR. Nanomedicine. 2011 Feb;7(1):88-96.
Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication. Chakravarthy KV, Bonoiu AC, Davis WG, Ranjan P, Ding H, Hu R, Bowzard JB, Bergey EJ, Katz JM, Knight PR, Sambhara S, Prasad PN. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10172-7.
MacDonald BA*, Chakravarthy KV*#, Davidson BA*, Mullan BA, Alluri R, Hakansson AP, Knight PR. Halothane Modulates the Type I Interferon Response to Influenza and Minimizes the Risk of Secondary Bacterial Pneumonia through Maintenance of Neutrophil Recruitment in an Animal Model. Anesthesiology. 2015 Sep;123(3):590-602. *authors contributed equally #corresponding author
Chakravarthy K, Boehm F, Sanhai-madar W (July 05, 2016) Superseding the Hourglass Effect Toward the Successful Commercialization of Nanotechnology in the Medical Sciences – We Require a Change in Perspective. Cureus 8(7): e670. doi:10.7759/cureus.670.
Krishnan V. Chakravarthy, MD, PhD, Frank J. Boehm, Paul J. Christo, MD, MBA; Nanotechnology: A Promising New Paradigm for the Control of Pain. Pain Med 2017 pnx131. doi: 10.1093/pm/pnx131.