Christopher K. Glass, MD, PhD

Professor of Cellular and Molecular Medicine
Professor of Medicine

Contact Information

Office: 858-534-6011
Lab: 858-534-8867
Fax: 858-822-2127

University of California, San Diego
Department of Cellular & Molecular Medicine
9500 Gilman Dr., MC 0651

ckg@ucsd.edu 

Lab Website







Dr. Glass’ primary interests are to understand the mechanisms by which sequence-specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages.  A major direction of his laboratory has been to define the genome-wide locations and functions of these proteins through the use of assays that are based on massively parallel DNA sequencing.  The combination of these technologies with molecular, genetic, lipidomic and cell-based approaches is providing new insights into mechanisms that regulate macrophage gene expression and function that are relevant to inflammatory diseases that include diabetes, atherosclerosis and neurodegenerative diseases.

 

Research Focus Areas:

Gene Expression and Regulation  |  Genetics and Genomics  |  Signal Transduction  |  Systems Biology

 

Dr. Glass' Publications (PubMed)

 

Selected Publications:

 

Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr;17(4):513-21. doi: 10.1038/nn.3668. Epub 2014 Mar 2. PubMed PMID: 24584051; PubMed Central PMCID: PMC4113004.

Heinz S, Romanoski CE, Benner C, Allison KA, Kaikkonen MU, Orozco LD, Glass, CK Effect of natural genetic variation on enhancer selection and function. Nature. 2013 Nov 28;503(7477):487-92. doi: 10.1038/nature12615. Epub 2013 Oct 13. PubMed PMID: 24121437; PubMed Central PMCID: PMC3994126.

Li P, Spann NJ, Kaikkonen MU, Lu M, Oh da Y, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. NCoR repression of LXRs restricts macrophage biosynthesis of insulin sensitizing omega 3 fatty acids. Cell. 2013 Sep 26;155(1):200-14. doi: 10.1016/j.cell.2013.08.054. PubMed PMID: 24074869.

Kaikkonen MU, Spann NJ, Heinz S, Romanoski CE, Allison KA, Stender JD, Chun HB, Tough DF, Prinjha RK, Benner C, Glass CK. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol Cell. 2013 Aug 8;51(3):310-25. doi: 10.1016/j.molcel.2013.07.010. PubMed PMID: 23932714; PubMed Central PMCID: PMC3779836.

Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27;498(7455):511-5. doi: 10.1038/nature12209. Epub 2013 Jun 2. PubMed PMID: 23728303; PubMed Central PMCID: PMC3839578.

Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation oF desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28;151(1):138-52. doi: 10.1016/j.cell.2012.06.054. PubMed PMID: 23021221; PubMed Central PMCID: PMC3464914.

Stender JD, Pascual G, Liu W, Kaikkonen MU, Do K, Spann NJ, Boutros M, Perrimon N, Rosenfeld MG, Glass CK. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell. 2012 Oct 12;48(1):28-38. doi: 10.1016/j.molcel.2012.07.020. Epub 2012 Aug 23. PubMed PMID: 22921934; PubMed Central PMCID: PMC3472359.