Richard Kolodner, PhD

Distinguished Professor of Medicine
Distinguished Professor of Cellular and Molecular Medicine
Member, Ludwig Institute for Cancer Research

Contact Information

Office: 858-534-7804
Fax: 858-534-7750

University of California San Diego
Ludwig Institute for Cancer Research
9500 Gilman Drive
La Jolla CA 92093-0660

rkolodner@ucsd.edu

Lab Web Site











Our laboratory is studying the genetic and biochemical mechanisms of genetic recombination, DNA repair and suppression of spontaneous mutations primarily using Saccharomyces cerevisiae as a model system. Work in S. cerevisiae falls in two interrelated areas - 1) the analysis of the proteins and genes that function in DNA mismatch repair; and 2) elucidation of the pathways that prevent translocations and other types of gross chromosomal rearrangements, and the analysis of the proteins that function in these pathways. The Kolodner lab also has research interests in the area of investigating the genetics of cancer susceptibility and development that follows on previous studies showing that a common cancer susceptibility syndrome, Lynch Syndrome (hereditary non-polyposis colorectal cancer), is due to inherited defects in DNA mismatch repair genes. This work is focused on understanding whether genes that prevent genome instability act as tumor suppressor genes in humans and whether defects in these genes can be therapeutically targeted.

 

Research Focus Areas:

DNA Replication and Repair  |  Genetics and Genomics  |  Biochemistry and Structural Biology  |  Signal Transduction  |  Stem Cell Biology

 

Dr. Kolodner's Publications (PubMed)

 

Selected Publications:

Putnam, CD, Hayes, TK, and Kolodner, RD.  Specific pathways prevent duplication-mediated genome rearrangements.  Nature.  2009;460:984-989.


Hombauer, H, Campbell, CS, Smith, CE, Desai, A, and Kolodner, RD.  Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair associated intermediates.  Cell.  2011;147:1040-1053.

Hombauer, H, Srivatsan, A, Putnam, CD, and Kolodner, RD.  Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication.  Science.  2011;334:1713-1716.

Putnam, CD, Soltero, S, Martinez, S, Hayes, TK, Chan, J, and Kolodner, RD.  Bioinformatic identification of genes suppressing genome instability.  Proc. Natl. Acad. Sci. USA.  2012;109:E3251-3259.

Bowen, N, Smith, CE, Srivatsan, A, Wilcox, SS, Griffith, JD, and Kolodner, RD.  Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins.  Proc. Natl. Acad. Sci. USA.  2013;110:18472-18477.