Susan Ferro-Novick, PhD

Distinguished Professor of Cellular and Molecular Medicine

Contact Information

Office: 858-246-0466
Lab: 858-534-7673
Fax: 858-534-7688


University of California, San Diego
9500 Gilman Drive
George Palade Laboratories, Room 318
La Jolla, CA 92093-0668

sferronovick@ucsd.edu

Lab Website







The Ferro-Novick laboratory studies how intracellular membranes communicate with each other to maintain homeostasis during cell stress.

 

Research Focus Areas:

Biochemistry and Structural Biology  |  ER Stress  |  Autophagy  |  Membrane Traffic

 

Dr. Ferro-Novick's Publications (PubMed)

 

Selected Publications:

 

Wang, J. et al.A requirement for ER-derived COPII vesicles in phagophore initiation. Autophagy 10, 708-709, doi:10.4161/auto.28103 (2014).

Tan, D. et al. The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway. Proc Natl Acad Sci U S A 110, 19432-19437, doi:10.1073/pnas.1316356110 (2013).

Bhandari, D. et al. Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits. Mol Biol Cell 24, 2727-2738, doi:10.1091/mbc.E13-02-0114 (2013).

Wang, J. et al. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Proc Natl Acad Sci U S A 110, 9800-9805, doi:10.1073/pnas.1302337110 (2013).

Chen, S., Novick, P. & Ferro-Novick, S. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. Nat Cell Biol 14, 707-716, doi:10.1038/ncb2523 (2012).

Lord, C. et al. Sequential interactions with Sec23 control the direction of vesicle traffic. Nature 473, 181-186, doi:10.1038/nature09969 (2011).

Barrowman, J., Bhandari, D., Reinisch, K. & Ferro-Novick, S. TRAPP complexes in membrane traffic: convergence through a common Rab. Nat Rev Mol Cell Biol 11, 759-763, doi:10.1038/nrm2999 (2010).

Lynch-Day, M. A. et al. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A 107, 7811-7816, doi:10.1073/pnas.1000063107 (2010).

Cai, Y. et al. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell 133, 1202-1213, doi:10.1016/j.cell.2008.04.049 (2008).

Cai, H. et al. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Nature 445, 941-944, doi:10.1038/nature05527 (2007).