In the News

January 24, 2017:

Congratulations to Nicolas Aznar on a very productive postdoctoral fellowship here at UCSD. He has recently secured funding from the French ARC agency (Association pour la recherche sur le cancer), which will support his transition for 2 years as he relocates to the CRCL (Centre de Recherche en Cancérologie de Lyon, France). Nico will work in the department of Cancer Cell Plasticity, embedded within a team led by Michelina Plateroti, who works on "development, cancer and stem cells". 


November 28, 2016:

Congratulations to Nicolas Aznar for the publication of his manuscript on the "Stress Polarity pathway" in the journal Elife.   The findings were widely covered by several news outlets:

UCSD News:

Cancer Facts: https://cancer-facts.info/?s=Pradipta+Ghosh

LifeScienceDaily: https://lifesciencedaily.com/medical-research/19361-uc-san-diego-researchers-identify-new-cell-fortifying-mechanism/

MyBioSource: https://www.mybiosource.com/learn/good-fences-protective-new-understandings-cancer-biology/

Fierce Biotech: http://www.fiercebiotech.com/research/how-diabetes-mainstay-metformin-may-prevent-tumors

Science Daily: https://www.sciencedaily.com/releases/2016/11/161121161807.htm

Latest Technology: http://latesttechnology.space/protein-that-protects-during-stress-sheds-light-on-how-diabetes-drug-prevents-tumors/

Stoneheartnewsletters: http://www.stonehearthnewsletters.com/how-metformin-prevents-tumors-ucsd-researchers/diabetes/


April 10, 2016: 

Congratulations to our graduate and undergraduate students and postdoctoral trainees for their recent accomplishments:

POST GRAD TRAINING IN MEDICINE: 
Gary Ma-- Matched here at UCSD for further training within the Internal Medicine Residency program 
Yash Mittal-- Matched here at Gastronetrology and Hepatology Fellowship program--starting July 2016--- will rejoin our lab in Sept 2017 for continuing his basic science training. 
Andrew Ong -- Matched at Santa Barbara Cottage for his internal medicine internship and Johns Hopkins for his radiology residency. 
Jeremy Lin-- Successfully got a position to train as a Physician Assistant at Duke University. 
 
INDUSTRY POSITIONS: 
Priyanka Mehlawat-- got position in Eli Lilly and Co.
Harsharan Dhillon-- got position in Vertex Pharmaceuticals
Krishna Midde-- got position in Ventana/Roche (AZ)
I-Chung Lo -- got position in Takeda Pharmaceuticals

March 30, 2016: 

Congratulations to Inma (Inmaculada Lopez_Sanchez), Gary, Nico and all coauthors for the acceptance of the following papers:

1. Ghosh, P., Tie, J., Muranyi, A., Singh, S., Brunhoeber, P., Leith, K., Bowermaster, R., Liao, Z., Zhu, Y., LaFleur, B., Tran, B., Desai, J., Jones, I., Croxford, M., Jover, R., Goel, A., Waring, P., Hu, S., Teichgraeber, V., Rohr, U.-P., Ridder, R., Shanmugam, K. & Gibbs, P. Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair Proficient Stage II Colon Cancer. Clinical Cancer Research : an official journal of the American Association for Cancer Research Accepted, In Press (2016).

2. Barbazan, J., Dunkel, Y., Li, H., Nitsche U., Janssen K-P, Messer, K., and Ghosh, P. Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer. Nature Scientific Rep. Accepted, In Press, 2016.

3. Ghosh, P. The untapped potential of tyrosine-based G protein signaling. Pharmacol. Res. Invited, peer-reviewed review article. Accepted, In Press, 2016.

4. Aznar, N., Midde, KK., Ghosh, P. Heterotrimeric G protein Signaling: Breaking the rules of engagement, space and time. Invited, Peer reviewed Article. In Press, BioEssays, 2015.

5. Lopez-Sanchez I, Ma GS, Pedram S, Kalogriopoulos N, Ghosh P. GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):287-93. PMID: 26514725.

6. Lopez-Sanchez I., Kalogriopoulos, N., Kabir, F., Midde, K., Wang, HH and Ghosh, P . Focal Adhesions are Concentrated Patches for Tyrosine-Based Signal Transduction via GIV/Girdin and G proteins. Mol Biol Cell. 2015 Dec 1;26(24):4313-24.. PMID: 26446841.

7. Ma, G., Lopez-Sanchez, I., Aznar, N., Midde, K., Pedram, S., Ciaraldi, T., Henry R.R. and Ghosh, P . GIV/Girdin serves as a molecular switch between insulin sensitivity and resistance. Mol Biol Cell, 2015 Nov 15;26(23):4209-23. PMID: 26378251.

Please join me in congratulating everybody on these collective successes. Cheers!

June 30, 2015: 

Congratulations to Inma (Inmaculada Lopez_Sanchez) on her Juan de la Cierva Fellowship which opens the doors for her to return to Spain and continue her journey towards independence. She will be starting in a new laboratory at CICbioGUNE (http://www.cicbiogune.es/). Please join me in congratulating her on this success. Cheers!

June 30, 2015: 

Ghosh Lab in the News surrounding the release of Nico's paper in eLife. Here are some URLs:

  • UCSD News:  http://ucsdnews.ucsd.edu/pressrelease/proteins_impact_on_colorectal_cancer_is_dappled
  • EurekaAlert: http://www.eurekalert.org/pub_releases/2015-06/uoc--pio063015.php
  • FierceBiotech Research: http://www.fiercebiotechresearch.com/story/dual-cancer-role-daple-attracts-research-team-uc-san-diego/2015-07-01
  • NZ Health Tech:  http://www.nzhealthtec.com/proteins-impact-on-colorectal-cancer-is-dappled/
  • News-Medical:  http://www.news-medical.net/news/20150701/UCSD-researchers-discover-cell-signaling-pathway-that-controls-initiation-progression-of-colorectal-cancer.aspx
June 1st 2015: Congrats to Nico on the acceptance of his manuscript reporting the discovery of Daple as a Guanine Nucleotide Exchange Factor for Trimeric G proteins.

Aznar, N., Midde, K., Dunkel, Y., Lopez-Sanchez, I., Pavlova, Y., Marvin, A., Barbazán, J., Murray, F., Nitsche, U., Janssen, K.P., Willert, K., Goel, A., Abal, M., Garcia-Marcos, M., and Ghosh, P. Daple is a Novel Non-Receptor GEF Required for Trimeric G protein Activation in Wnt Signaling. June 30, eLife, 2015.

May 1st 2015: 

Ghosh Lab in the News surrounding the release of Gary and Nico's paper in PNAS. Here are some URLs:

  • International Business Times: http://au.ibtimes.com/scientists-demonsrate-how-reset-diseased-cell-1445386
  • Tuning Cells in the Key of G Proteins (Genetic Engineering and BIotechnology): http://www.genengnews.com/gen-news-highlights/tuning-cells-in-the-key-of-g-proteins/81251224/
  • Eureka Alert and AAAS: http://www.eurekalert.org/pub_releases/2015-05/uoc--htr050115.php
  • Science Codex: http://www.sciencecodex.com/how_to_reset_a_diseased_cell-156324
  • Science Daily: http://www.sciencedaily.com/releases/2015/05/150501125445.htm
  • NewsFee: http://newsfee.com/news/list/view/1681807/how-to-reset-a-diseased-cell
  • Beyond the dish: https://beyondthedish.wordpress.com/2015/05/11/using-peptides-to-reset-a-diseased-cell/
  • Health Innovations: http://health-innovations.org/2015/05/04/how-to-reset-a-diseased-cell/
  • Bioengineering : http://bioengineer.org/how-to-reset-a-diseased-cell/
  • All Web News: http://www.allwebsolutions.net/health/how-to-reset-a-diseased-cell/
  • Physics.org: http://phys.org/news/2015-05-reset-diseased-cell.html
  • Science Newsline: http://m.sciencenewsline.com/news/2015050120370012 
  • Science 2.0: http://www.science20.com/news_articles/how_to_reset_a_diseased_cell-155275 

April 2015: Congrats to Gary, Nico and coauthors on the acceptance of their paper in PNAS (Direct Submission)!

Ghosh Lab in the News surrounding the release of I-Chung's paper in Dev Cell. Here are some URLs:

  • UCSD News: https://health.ucsd.edu/news/releases/Pages/2015-04-09-g-proteins-and-golgi-body.aspx
  • Science Daily: http://www.sciencedaily.com/releases/2015/04/150409150810.htm
  • Bioquick News: http://www.bioquicknews.com/node/2547
  • Medical Express: http://medicalxpress.com/news/2015-04-golgi-trafficking-proteins.html

Mar 2015: Lawrence Liu, an undergraduate student trainee in the Ghosh lab wrote this article on Circulating Tumor Cells in SqOnline, a journal for and by the UCSD biology student community. Firooz Kabir, the editor is also an undergraduate student trainee in the Ghosh lab. Congrats to Lawrence and Firooz! 

URL Link: https://sqonline.ucsd.edu/2015/03/ctc-locating-tumor-cells/ 

Mar 2015: The Ghosh lab (jointly with Dr Hatim Husain) receives the Translational and Clinical Cancer Research Award from the Moores Cancer Center (UCSD).

Feb 2015: Changsheng's paper (MBoC 2014) was featured online on Global Medical Discovery [ISSN 1929-8536] (https://globalmedicaldiscovery.com ). It was also shared with the pharmathis articleceutical and scientific community.

Feb 2015: Congrats to I-Chung and coauthors on the acceptance of his paper into Dev Cell!

Jan 2015: Congrats to Krishna on the acceptance of his paper in PNAS (Direct Submission)!

June 2014: The Ghosh Lab receives a R01 award from the National Institute of Diabetes, Digestive and Kidney Diseases  to study the role of G proteins in modulation of Liver fibrosis. Thank you NIDDK/NIH!

nih_logo2

June 2014: Inmaculada Lopez-Sanchez, Ph.D., a postdoctoral fellow in the Ghosh lab is awarded the AHA postdoctoral Fellowship award. This funding supports Inma for 2 years fr a total of $100,000 in support of research project on Insulin resistance/Diabetes. Thank you, AHA!

May 2014: Krishna Midde, Ph.D., a postdoctoral fellow in the Ghosh lab is awarded the Basic and Translational Postdoctoral Fellowship Award. This funding was approved by Komen's board of directors through a 3-year grant for a total of $180,000 in support of his research project entitled "A novel therapeutic and diagnostic target in triple negative breast cancers”. Thank you, Komen Foundation!

Jan 2014: Gary Ma, a 3rd year Medical Student @ UCSD and a Doris Duke research fellow in the Ghosh Laboratory is awarded the Carmel AFMR Scholar Award by the Western Region of the American Federation of Medical Research. Congrats! Gary  

July 2013: Dr. Pradipta Ghosh Receives Clinical Research Mentorship Grant from Doris Duke Charitable Foundation – Not long ago, she was the mentee; now, she’s the mentor

June 2013: Congratulations to Gary S Ma for securing the coveted DDCF Clinical Research Mentorship award. He will be spending a whole year in the Ghosh lab training in cell and molecular biology.  Thank you DDCF!

Doris Duke Charitable Foundation

June 2013: The Western States Affiliate Research Committee of the American Heart Association (AHA) has approved activation of a Medical Student Research Program award for Margaret to train in the Ghosh lab during the summer of 2013. Congratulations to Margaret Chiu. Thank you AHA!

June 2013: Yash Mittal, our former medical student research scientist and Sarah Rogers Fellow was selected for Residency program in Internal Medicine at Yale. Congrats Yash. May the force be with you. 

June 2013: Warm welcome to new arrivals in the Ghosh Lab-- Krishna Midde (PhD from UNTHSC), Arjun Patel, Priyal Thakur, Lawrence Liu, Gary Ma and Margaret Chiu. It is surely going to be a busy summer in the Ghosh Lab. 

April 2013: The Ghosh Lab receives the US DOD Visionary Postdoctoral Fellowship award that will support Dr Melanie Laederich during her 3 years of postdoctoral training as she tries to solve how colorectal cancer cells invade using a novel signaling pathway. Thank you, Department of Defense!

CDMRP logo

Oct 2012: The American Cancer Society IRG has just renewed funding for the Ghosh lab to continue their studies on breast cancer invasion for another year. Thank you ACS!

June 2012: The Ghosh Lab receives a R01 award from the National Cancer Institute to study the role of G proteins in modulation of growth factor signaling. Thank you NCI/NIH!

logos for Department of Health and Human Services USA, National Institutes of Health, National Cancer Institute

Sept 2011: GIVing Migration a Boost: Read Editor's Summary of New Ghosh Lab Publication: http://stke.sciencemag.org/cgi/content/summary/sigtrans;4/192/ra64

March 2011: Ghosh Lab's reports the discovery of a novel biomarker in colorectal cancer.    http://www.newsrx.com/newsletters/Life-Science-Weekly/2011-03-15/25031520115457LS.html

June 2010: Pradipta Ghosh receives Clinical Scientist Development Award (CSDA) from the Doris Duke Charitable Foundation: 

March 2010: Mikel Garcia-Marcos and Pradipta Ghosh's work published in J. Biol. Chem (Feb 2010) was cited in Faculty of 1000 as "an interesting article that unequivocally demonstrates the structural basis for the mechanism by which G-alpha-i3 is regulated by GIV/Girdin, a novel non-receptor guanine-nucleotide exchange factor (GEF). The intriguing observation presented here may pave the way for the discovery of other GEFs that are potentially involved in the regulation of different members of the super-family of G proteins"

December 2009: Pradipta Ghosh selected as Gregory J. Gurtner Memorial Lecturer by Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, MO. 

June 2009: Pradipta Ghosh awarded Career Awards for Medical Scientists (CAMS) from Burroughs Wellcome Foundation. Thank you, BWF!

BWF Collaborative Research Travel Grants

March 2008: Pradipta Ghosh awarded Research Scholar Award from Amer Gastro Association:

News coverage for Ghosh et al., JCB Article, 2008: "Driven to the Brink by a G protein"

Pradipta Ghosh awarded Career Award for Medical Scientists from Burroughs Wellcome Fund:

Jason Ear presents his work at the 2009 UCSD Annual Undergraduate Research Conference:

Jason Ear Certification