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Updated Lab photo

Pradipta Ghosh, MD

Pradipta Ghosh, MDThose who knew Pradipta as a child would agree that she is easily bored if not constantly challenged. Building a knowledge base that is very broad and deep was her way to take on the challenge in exploring anything that she knew little or nothing about. After graduating as the Best Outgoing Student in a nationwide ranking, from the top medical school in India, Pradipta came to US in 2001 in search of the next challenge, that of a career in biomedical science. This twist in career was prompted by a famous quote that she had stumbled upon -- "Medicine is not only an art; it is also a science. It does not consist of compounding pills and plasters; it deals with the very processes of life, which must be understood before they may be guided". Determined to get trained in a good laboratory, she applied to Universities in US with little or no hope of hearing back. Her dream materialized when her resume trickled through the system and fell in the hands of Stuart Kornfeld at Washington University St Louis, MO, a seasoned physician-scientist and a great mentor, an astute judge of character and talent, who agreed to give Pradipta an opportunity to train in his laboratory. Pradipta was quick to realize that this rare opportunity comes with extraordinary challenges ahead because she was about to enter a dual-career path, that of a physician-scientist, with no prior training as a scientist and years of rigorous internship, residency and fellowship in US ahead of her. She was introduced to experimental medicine in the Kornfeld laboratory, where she took the very first steps in her scientific career. Soon her vocation became her passion and what followed during the next 18 months was nothing short of magic. Her work investigated how adaptor proteins, GGAs and AP1&2, affected sorting of Mannose-6 Phosphate Receptors (MPRs) and directly led to the discovery of a layer of complexity in the multi-step sorting of the receptor in-and-out of the Golgi. Through her publications within the next year, a novel paradigm emerged in the field of protein trafficking where series of ying-yang phospho- and dephosphorylation events regulate each step of receptor trafficking based on the temporospatial distribution of the respective kinases or phosphatases. If St Louis winters were cold, or summers hot, Pradipta would not know because she was in the lab round-the-clock acquiring the scientific tools and building her technical expertise. She recalls that the learning curve was steep, but she enjoyed every moment of the journey, gaining unique perspective and broadening her horizon with every passing day. She describes her time spent in the Kornfeld lab as the most formative years of her scientific career because it served as a solid foundation for the years to come.

In 2003, Pradipta moved to University of California, San Diego (UCSD) to begin her clinical training in Internal Medicine. After fast-tracking through her internship and residency in the physican-scientist training pathway, she joined the UC San Diego Gastroenterology Fellowship Program in 2005. A year later, she began her postdoctoral research training in the George Palade laboratories under the mentorship of Dr. Marilyn G. Farquhar, PhD Equipped with the skills of a biochemist, this is where she honed her skills as a cellular and molecular biologist, and further broadened her horizon by incorporating systems biology, computational modeling and bioinformatics into her research program. Her postdoctoral work on a newly discovered protein, GIV/Girdin, established the presence of a novel class of signaling molecules and unraveled hitherto unknown functions of these molecules in cell biology and pathophysiology. In 2008 she graduated from the Gastroenterology fellowship program and joined as an Assistant Professor on tenure track in the department of Medicine at UC San Diego. Ongoing work in her laboratory seeks to identify novel signal amplifiers/rheostats in a systematic and unbiased way using a three-pronged approach. Using these approaches her laboratory has already identified new rheostats with surprising functions during cellular processes such as membrane-trafficking, autophagy, survival, apoptosis, mitosis, differentiation and migration. Once systematically applied, these approaches have the real potential to revolutionize our understanding of signal transduction and the diverse biological processes and disease states that they control.

Dr Ghosh currently devotes ~10% of her time in clinical services. Every Friday morning she either sees patients in a subspeciality outpatient clinic (Hepatology) or performs procedures in endoscopy suits at the VA Medical Center, La Jolla.

Pradipta's Research Mentors:

  • (August 2001 - May 2003): Stuart A. Kornfeld, MD
  • (September 2006 - November 2008): Marilyn G. Farquhar, PhD

Professional Experience: 

07/16 - present Professor (with tenure), Dept of Medicine, Univ of Calif, San Diego, CA

07/16 - present Professor (with tenure), Dept of Cell and Molecular Medicine, Univ of Calif, San Diego, CA

10/15 - 06/16 Associate Professor (with tenure), Dept of Cell and Molecular Medicine, Univ of Calif, San Diego, CA

07/12 - 06/16 Associate Professor (with tenure), Dept of Medicine, Univ of Calif, San Diego, CA

12/08 – 06/12 Assistant Professor, Dept of Medicine, Univ of Calif, San Diego, CA

09/05 – 11/08 Clinical Fellow, GI Division, Dept of Medicine; Research Fellow, Department of Cell and Molecular Medicine; Univ of Calif, San Diego, CA

08/04 - 08/05 Resident, Physician-Scientist Training Program, Internal Medicine, Dept of Medicine, Univ of Calif, San Diego, CA

08/03 - 08/04 Intern, Physician-Scientist Training Program, Internal Medicine, Dept of Medicine, Univ of Calif, San Diego, CA

Awards & Honors

  • 2013- Medical Student Research Mentor Award (American Heart Association)
  • 2013- Mentor on DOD Visionary fellowship award (CDMRP)
  • 2013- Clinical Research Mentor Award (Doris Duke Charitable Foundation)
  • 2010- Clinical Scientist Development Award (CSDA, Doris Duke Charitable Foundation)
  • 2010- RSA(AGA) Rising Star, Europe-US Joint Session Lecturer, DDW, New Orleans, USA.
  • 2009- Gregory J. Gurtner Memorial Lecturer, Washington U, St Louis, MO, USA. 
  • 2009- Career Awards for Medical Scientists (Burroughs Wellcome Foundation)
  • 2008- American Gastroenterology Association Research Scholar Award (Foundation for Digestive Health and Nutrition, FDHN) 

Lab Manager

Nina Sun Nina Sun
Email:
nnsun@ucsd.edu

Postdoctoral Fellows / Graduate Students / Visiting Scholars

Ying Dunkel

Ying Dunkel, MD, PhD
MD & PhD in Pathology, China Medical University
Staff Research Associate, Ghosh Lab (October, 2010-Present)

ydunkel@ucsd.edu; yingdunkel@yahoo.com

Cristina Rohena, PhD

Cristina Rohena, PhD
Doctorate in Cell and Structural Biology (University of Texas Health Science Center at San Antonio)
Fellow, Moores Cancer Center.
Postdoctoral Fellow (2015-Present)
Cancer Therapeutics (CT2) T32 Fellow, Moores Cancer Center

Jason Ear, PhD

Jason Ear, PhD
Doctorate in Cell and Developmental Biology (University of California, Los Angeles)
Postdoctoral Fellow (2015-Present)

 

Lee Swanson Lee Swanson
Biomedical Sciences Graduate Student (2015-Present)
GI Division T32 Predoctoral Fellow (2015-2018) 
  Nicholas (Nick) Kalogriopoulos
Biomedical Sciences Graduate student,
Batch of 2013,
NCI Cancer Cell Biology Predoctoral Fellow (Aug 2014-July 2016)
Email: nkalogri@ucsd.edu
Nicolas Aznar

Nicolas Aznar, PhD
MS and PhD in Molecular, Cellular and Cancer Biology,
Laboratoire de Génétique Moléculaire, Signalisation et Cancer,
The National Center For Scientific Research (CNRS), Lyon, FRANCE.
Postdoctoral Fellow, Ghosh Lab (March, 2011- Present)

Email:naznar@ucsd.edu

 Linda Joosen Linda P. Joosen, B.Sc, Molecular Biology
Staff Research Associate (2016 - present)
Specialization: Molecular Cytology, Genetics and Cell biology; Live cell imaging

 

 

Undergraduate Student Employees

Anokhi Saklecha

Anokhi Saklecha
Undergraduate Student, UCSD
Student Research Assistant (2015-Present)
Intern at University of California, San Diego School of Medicine, United States

Camille Delbrook

​Camille Delbrook
Undergraduate Student Research Assistant, UCSD
(2016-Present)

 
Evelyn Yang

Evelyn Yang
Undergraduate Student Research Assistant, UCSD
 (2016-Present)

 

Somya Moyya

Somya Moyya
Undergraduate Student Research Assistant, UCSD
 (2016-Present)

Trina Amog Trina Amog
Undergraduate Student Research Assistant
Ghosh Lab (2014-Present)

Email: tamog@ucsd.edu

Daniel Tang Daniel Tang
Undergraduate Student Research Assistant, UCSD
 (2016-Present)
Yogitha Chareddy Yogitha Chareddy
Undergraduate Student
Ghosh Lab (2016-Present)

 

Precious Moman Precious Moman
Undergraduate Student, SDSU
Student Research Assistant (2016-Present)

Past Lab Members

Jasmine (Ping-Ping) Wong (2008-2010)
Undergraduate Student, Biology
(Currently working for Pfizer)

Jessica L. Mendez (2009-2010)
Undergraduate Student, Biology
Current Status: Medical Student, University of Wisconsin, Madison

Patrick Kiertrsunthorn (2009-2010)
Undergraduate Student, Biology
Current Status: Medical Student, University of Alabama

Michelle Aida (2009-2010)
Undergraduate Student, Biology
Current Status: Intern Pharmacist at Kaiser Permanente, Los Angeles, CA

Jason Ear
Undergraduate student trainee, Ghosh Lab (2008-2010);
McNair Scholar
Current Status: Graduate (PhD) student, UCLA.

Yohan Penny
Undergraduate student trainee, Ghosh Lab (Nov 2009-March 2011)
Current Status: Research Associate ROKA Bioscience, San Diego, CA.

Changsheng Lin, PhD
Postdoctoral Fellow, Ghosh Lab (2009-2010
Current Status: Postdoctoral fellow at The David J Gladstone Research Institute, San Francisco, CA

Yash Mittal (2009-2012)
Graduate Medical Student, UC San Diego
Sarah Rogers Fellow, 2010
Current Status: First year medical student, Yale University School of Medicine

Victor Tran (2008-2012)
Undergraduate Student, Biochem and Cell Biology

Priyal Thakur
Masters Student in Bioengineering
Ghosh Lab (2013-2014)

Magda Holda
Undergraduate Student
Bioengineering: Biotech
Ghosh Lab (April 2011-Jun 2014)

Priyanka Mehlawat
Research Assistant (Volunteer)
Ghosh Lab 2014-2015
Current Status: Scientist, Eli Lilly, San Diego

Olivia Chang
Undergraduate student, UCSD
Student Research Assistant, Ghosh Lab (2014-2015)

Krishna Midde, PhD
PhD in Biochemistry and Chemistry
University of Northern Texas Health Health Sciences (UNTHSC)
Postdoctoral Fellow, Ghosh Lab (June 2013-2015)
Current Position: Staff Scientist, Ventana, Inc., Tucson Arizona.

Jacky W. Lu
Undergraduate Student, UCSD
Student Research Assistant (2015-Present)
Senior Honors Thesis Program (2016-2016)

Firooz Kabir
Undergraduate Student
Ghosh Lab (2013-2016)

 

Christine Leiva (2010 - 2012)
"Bill and Melinda Gates Scholar"
Undergraduate Student, Hum Biol and Cell Biology

Andrew Ong
Masters Student, Biology
Ghosh Lab (Dec, 2008-2012)
Current Status: Medical student, St. Louis University

Melanie B. Laederich, PhD
PhD in Cellular and Developmental biology,
Oregon Health & Science University,
Postdoctoral Fellow, Ghosh Lab (June, 2012-2013)

Yelena Pavlova
(Lab Manager; Mar 2009-April 2013)

Edgar Zatik Zatikyan
Undergraduate Student (2012-2013)

Dademos Taye
Undergraduate Student (2012-2013)

Priya Chakrabarti
Undergraduate Student (2011-2013)

Shabnam Pedram
Masters in Biology Student, (2011-2013)
Current Status: First year student at Ostrow School of Dentistry, USC

Jeremy Lin
Masters in Biology Student (2012-2013)

Margaret Chiu
Medical Student (2013-Present)
AHA Student Research Award (2013-2014)

Gary S. Ma
Medical Student, UCSD
Doris Duke Research Fellow (2013-2014)
Current Status: 4th Year Medical Student, UCSD

Fang He, MD, PhD
Visiting Scholar, Ghosh Lab (2014-2015)
Current Status: Associate Professor, Center of Infectious Diseases, West China Hospital, Sichuan University, PRC

Inmaculada Lopez-Sanchez, PhD
Postdoctoral Fellow (2011-2015)
AHA Fellow (2014-2015)
Current Status: Recipient of Juan de la Cierva Fellowship; CICbioGUNE, Spain

I-Chung Lo, PhD
Doctorate in Cell Biology
National Cheng Kung University College of Medicine
Postdoctoral Fellow (2011-2016)
Current Position: Staff Scientist at Takeda Pharmaceuticals, San Diego, CA.

Arjun Patel
MS Biology student
Ghosh Lab (2014-2015)
Current Position: Medical Student (M.D)

Harsharan Dhillon
Undergraduate Student
Ghosh Lab (2013-2016)

Ninvita Givarkes
Undergraduate Student, UCSD
Ghosh Lab (2015-2016)

Lawrence Liu
Undergraduate Student
Ghosh Lab (2013-2015)