Ghosh Lab Research

We study the cell biology of signal transduction
  • Growth factor-recptor tyrosine kinases, G-protein coupled receptors, TGFBr... and their downstream signaling cascades
that drive diverse cellular functions/events
  • Migration/invasion
  • Cell polarity/Cell-Cell Junctions
  • EMT/MET
  • Energetic Stress
  • Trafficking/secretion
  • Growth/metabolism
  • Survival/apoptosis
  • Autophagy
  • Cell cylce/mitosis

during pathologic processes such as:

Breast and Colorectal Cancer Invasion, Liver Fibrosis, Neurodegenerative disorders such as Alzheimers and Parkinson's, Schizophrenia, Developmental Disorders of the Brain, Intestinal Barrier Function. Neoplastic Transformation, etc. 

Tumor Growth Illustration

using tools:
  • Standard protein chemistry
  • Standard molecular biology
    Computational chemistry (collaborative)
  • Immunofluorescence
  • Electron microscopy and Immuno-EM
  • Immuno-histochemistry
  • Live-cell imaging
in a variety of model systems...
  • Mammalian cells in 2D and 3D cultures
  • Rodents
  • C. Elegans
to understand the pathogenesis of, and discover therapeutic targets in...
  • Colorectal cancer
  • Breast cancer
  • Aging, inflammation, metabolism
  • Renal Injury (nephrotic syndrome, acute tubular nectrosis)
  • Liver Injury/inflammation/cirrhosis/HCCa
  • Neuronal signaling, pain & addiction
  • Alzheimers, Parkinson's, and Schizophrenia,
  • Type II  DM/Insulin Resistance