Individuals produce billions of blood cells every day. The stimuli and genes that allow individual hematopoietic stem cells (HSCs) to produce mature progeny such as red blood cells, white blood cells, lymphocytes and platelets has been studied in considerable depth and serves as a model system in developmental biology. However, how the multipotent HSCs is derived during embryogenesis remains poorly understood, especially in the human system.
My studies focus on this beginning stage of blood development: the transition from embryonic stem cell to hematopoietic stem cell.
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