Research Opportunities

Scholarly Activities  |  Research Elective  |  Resident Research Symposium 
Research Conferences  |  Publications, Classes of 2014-2016
  |  Residents' Research Topics

UC San Diego internal medicine residents at American Thoracic Society Annual Meeting in 2016.

UC San Diego internal medicine residents at American Thoracic Society Annual Meeting in 2016.

Scholarly Activities

Internal medicine residents at American College of Cardiology meeting in April 2016.The UC San Diego Internal Medicine Residency Program is a highly academic training program. The excellent research and clinical faculty help the residents achieve the goals of participating in scholarly activities. It is our purpose to train residents in both clinical medicine and the scientific basis of diagnostic and therapeutic interventions.

Every resident participates in a scholarly project that is presented to peers. Additionally, they are responsible for other teaching activities in evidence-based medicine, journal club, and morbidity and mortality conferences.

Pictured, from left: Drs. Rohit Mital (R2), Jonathan Harrison (R2), Misha (Mikhail) Narezkin (R2), Darrin Wong (R3) and Neil Beri (R2) at the American College of Cardiology meeting in April 2016.

Research Elective

Residents may elect to undertake a two-month research elective under the mentorship of a faculty member during their second or third year. Many great mentors are accessible at UC San Diego; the faculty members place a high value on mentorship. Each resident is assigned to a faculty mentor during the internship year. Residents may identify other mentors as their specialty and research interests come into focus. 

Research projects have been diverse, from epidemiology to clinical studies to basic science/bench research to quality improvement. Many of the research projects have gone on to be presented at national meetings and to peer-reviewed manuscripts.

The research projects are abstracted and placed on the residency website and presented at teaching conferences each year. Each academic year, the residents compete for four slots during the Medicine Grand Rounds series to present their research results. 

The two research elective months may be consecutive or separate.

Above right: Dr. Jisha Joshua (R2 in 2015-2016) at the 2016 American Thoracic Society Annual Meeting.

Below left: Rebecca Kim (R2), Janki Patel (R3) and Steven Lin (R3) at the 2015 Annual Meeting of the AASLD. Below right: Darrin Wong (R3) at the 2015 Annual Meeting of the American Heart Association.

Resident Research Symposium

At the end of the year, residents present the results of their research projects during a symposium coordinated by the residency program. The general academic community is invited in addition to the housestaff and their mentors. This is a great opportunity for residents to showcase their work as well as a supportive environment to gain experience in preparing and delivering an academic talk.

Research Conferences

Resident Jenny Yang at ATS Conference 2016.House staff are encouraged to submit and present their research findings at regional and national conferences. A vast majority do so. All residents receive three academic days for attending conferences, with the residency program providing an educational stipend toward these conferences.

At right: Dr. Jenny Yang (R1 in 2015-2016) at 2016 American Thoracic Society Annual Meeting.

Resident Publications, Classes of 2014-2016

Excluding the Physician-Scientist Training Pathway

  1. Shah KS, Marston NA, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney J, Schreiber D, deFilippi C, Hogan CJ, Diercks DB, Limkakeng A, Anand IS, Wu AH, Clopton P, Jaffe AS, Peacock WF, Maisel AS. Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: Results from the chopin trial. Acad Emerg Med. 2015;22:554-563  |  PubMed
  2. Shah K. Picking a fellowship: Getting your priorities straight in a timely fashion. J Am Coll Cardiol. 2015;66:972-975 | PubMed 
  3. Pearlman M, Kwong WT. A long and distant journey: A case of rectal cancer with metastasis to the orbit. Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology. 2015;28:151-152 | PubMed
  4. Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, Seki E, Sirlin CB, Loomba R. Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2015;13:561-568 e561 |  PubMed
  5. Marston NA, Shah KS, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Daniels LB, Hollander JE, Apple F, Nagurney J, Schreiber D, deFilippi C, Diercks D, Limkakeng A, Anand IS, Wu AH, Jaffe AS, Peacock WF, Maisel AS. Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: Results from the chopin trial. Emergency medicine journal : EMJ. 2015  |  PubMed
  6. Marston N, Brown JP, Olson N, Auger WR, Madani MM, ​​Wong D, Raisinghani AB, DeMaria AN, Blanchard DG. Right ventricular strain before and after pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension. Echocardiography. 2015;32:1115-1121 | PubMed
  7. Maisel AS, Shah KS, Barnard D, Jaski B, Frivold G, Marais J, Azer M, Miyamoto MI, Lombardo D, Kelsay D, Iqbal N, Taub PR, Kupfer K, Lee E, Clopton P, Zile M, Greenberg B. How b-type natriuretic peptide (bnp) and body weight changes vary in heart failure with preserved ejection fraction compared to reduced ejection fraction: Secondary results of the habit (hf assessment with bnp in the home) trial. Journal of cardiac failure. 2015  |   PubMed
  8. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D, Genetics of NiTC. Heritability of hepatic fibrosis and steatosis based on a prospective twin study. Gastroenterology. 2015  |  PubMed
  9. Lin SC, Heba E, Wolfson T, Ang B, Gamst A, Han A, Erdman JW, Jr., O'Brien WD, Jr., Andre MP, Sirlin CB, Loomba R. Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat using a new quantitative ultrasound technique. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2015;13:1337-1345 e1336  |  PubMed
  10. Lin KJ, Ching A, Edmonds KP, Roeland EJ, Revta C, Ma JD, Atayee RS. Variable patterns of continuous morphine infusions at end of life. J Palliat Med. 2015;18:786-789   |  PubMed
  11. Lee NS, Blanchard DG, Knowlton KU, McDivit AM, Pretorius V, Madani MM, Fedullo PF, Kerr KM, Kim NH, Poch DS, Auger WR, Daniels LB. Prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension. Pulmonary circulation. 2015;5:313-321 | PubMed
  12. Krummen DE, Hayase J, Vampola SP, Ho G, Schricker AA, Lalani GG, Baykaner T, Coe TM, Clopton P, Rappel WJ, Omens JH, Narayan SM. Modifying ventricular fibrillation by targeted rotor substrate ablation: Proof-of-concept from experimental studies to clinical VF. Journal of cardiovascular electrophysiology. 2015 | PubMed
  13. Egnatios J, Kaushal K, Kalmaz D, Zarrinpar A. Video capsule endoscopy in patients with chronic abdominal pain with or without associated symptoms: A retrospective study. PLOS ONE. 2015;10:e0126509 | PubMed
  14. Dubin SM, Kwong WT, Kalmaz D, Savides TJ. Low yield of routine duodenal biopsies for evaluation of abdominal pain. World Journal of Gastroenterology 2015;21:7495-7499 | PubMed
  15. Do DH, Hayase J, Tiecher RD, Bai Y, Hu X, Boyle NG. ECG changes on continuous telemetry preceding in-hospital cardiac arrests. J Electrocardiol. 2015 |  PubMed
  16. Das S, Huynh D, Yang H, Ceponis A, Kavanaugh A. Salivary gland ultrasonography as a diagnostic tool for secondary Sjögren syndrome in rheumatoid arthritis. The Journal of Rheumatology. 2015;42:1119-1122 | PubMed
  17. Bruggeman AR, Heavey SF, Ma JD, Revta C, Roeland EJ. Lack of documentation of evidence-based prognostication in cancer patients by inpatient palliative care consultants. J Palliat Med. 2015;18:382-385 | PubMed
  18. Arulanandan A, Ang B, Bettencourt R, Hooker J, Behling C, Lin GY, Valasek MA, Ix JH, Schnabl B, Sirlin CB, Loomba R. Association between quantity of liver fat and cardiovascular risk in patients with nonalcoholic fatty liver disease independent of nonalcoholic steatohepatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2015;13:1513-1520 e1511 | PubMed
  19. Xue Y, Iqbal N, Chan J, Maisel A. Biomarkers in hypertension and their relationship with myocardial target-organ damage. Current hypertension reports. 2014;16:502 | PubMed
  20. Shah KS, Maisel AS. Novel biomarkers in heart failure with preserved ejection fraction. Heart failure clinics. 2014;10:471-479 | PubMed http://www.ncbi.nlm.nih.gov/pubmed/24975910
  21. Sait AS, Kuo A, Bettencourt R, Bergstrom J, Allison M, von Drygalski A. Risk assessment for coronary heart disease in patients with haemophilia: A single centre study in the united states. Haemophilia: the official journal of the World Federation of Hemophilia. 2014;20:763-770 | PubMed
  22. Pearlman M, Loomba R. State of the art: Treatment of nonalcoholic steatohepatitis. Current opinion in gastroenterology. 2014;30:223-237 | PubMed
  23. Marston NA, Maisel AS. The prognostic value of copeptin in patients with acute chest pain. Expert review of cardiovascular therapy. 2014;12:1237-1242 | PubMed
  24. Marston NA, Auger WR, Madani MM, Kimura BJ, Strachan GM, Raisinghani AB, DeMaria AN, Blanchard DG. Assessment of left atrial volume before and after pulmonary thromboendarterectomy in chronic thromboembolic pulmonary hypertension. Cardiovascular ultrasound. 2014;12:32 | PubMed
  25. Marston N, Kehl D, Copp J, Nourbakhsh N, Rifkin DE. Alkalotics anonymous: Severe metabolic alkalosis. The American journal of medicine. 2014;127:25-27 | PubMed
  26. Lee NS, Daniels LB. Personalized CHF treatment: PCT to guide therapy in heart failure patients. International journal of cardiology. 2014;176:307-308 | PubMed
  27. Lee NS, Auger WR, Pretorius V, Blanchard DG, Daniels LB. Coronary artery-to-pulmonary artery collaterals in chronic thromboembolic pulmonary hypertension. Circulation. Cardiovascular imaging. 2014;7:962-966 | PubMed
  28. Krummen DE, Hayase J, Morris DJ, Ho J, Smetak MR, Clopton P, Rappel WJ, Narayan SM. Rotor stability separates sustained ventricular fibrillation from self-terminating episodes in humans. J Am Coll Cardiol. 2014;63:2712-2721 | PubMed
  29. Henry RR, Mudaliar S, Ciaraldi TP, Armstrong DA, Burke P, Pettus J, Garhyan P, Choi SL, Jacober SJ, Knadler MP, Lam EC, Prince MJ, Bose N, Porksen N, Sinha VP, Linnebjerg H. Basal insulin peglispro demonstrates preferential hepatic versus peripheral action relative to insulin glargine in healthy subjects. Diabetes care. 2014;37:2609-2615 | PubMed
  30. Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced mda adducts: Implications for development of an atheroprotective vaccine. Journal of lipid research. 2014;55:2137-2155 | PubMed
  31. Bhandari A, Kalmaz D. Jejunal post-polypectomy syndrome. Endoscopy. 2014;46 Suppl 1 UCTN:E133-134 | PubMed
  32. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. Mcp-1 binds to oxidized ldl and is carried by lipoprotein(a) in human plasma. Journal of lipid research. 2013;54:1877-1883 | PubMed
  33. Richards M, Di Somma S, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Clopton P, Filippatos GS, Anand I, Ng L, Daniels LB, Neath SX, Shah K, Christenson R, Hartmann O, Anker SD, Maisel A. Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: Results from the bach study (biomarkers in acute heart failure). JACC. Heart failure. 2013;1:192-199 | PubMed
  34. Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin CB, Loomba R. Insulin resistance increases MRI-estimated pancreatic fat in nonalcoholic fatty liver disease and normal controls. Gastroenterology research and practice. 2013;2013:498296 | PubMed
  35. Patel NS, Peterson MR, Brenner DA, Heba E, Sirlin C, Loomba R. Association between novel mri-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Alimentary pharmacology & therapeutics. 2013;37:630-639 | PubMed
  36. Olson MD, Phreaner N, Schuller JL, Nguyen DT, Katz DF, Aleong RG, Tzou WS, Sung R, Varosy PD, Sauer WH. Effect of catheter movement and contact during application of radiofrequency energy on ablation lesion characteristics. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2013;38:123-129 | PubMed
  37. Iqbal N, Choudhary R, Chan J, Wentworth B, Higginbotham E, Maisel AS. Neutrophil gelatinase-associated lipocalin as diagnostic and prognostic tool for cardiovascular disease and heart failure. Expert opinion on medical diagnostics. 2013;7:209-220 | PubMed
  38. Hayase J, Tung R, Narayan SM, Krummen DE. A case of a human ventricular fibrillation rotor localized to ablation sites for scar-mediated monomorphic ventricular tachycardia. Heart rhythm : the official journal of the Heart Rhythm Society. 2013 | PubMed
  39. Hayase J, Patel J, Narayan SM, Krummen DE. Percutaneous stellate ganglion block suppressing VT and VF in a patient refractory to VT ablation. Journal of cardiovascular electrophysiology. 2013 | PubMed
  40. Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vazquez J, Li AC, Miller YI. Control of angiogenesis by aibp-mediated cholesterol efflux. Nature. 2013;498:118-122 | PubMed
  41. Doycheva I, Patel N, Peterson M, Loomba R. Prognostic implication of liver histology in patients with nonalcoholic fatty liver disease in diabetes. Journal of diabetes and its complications. 2013;27:293-300 | PubMed
  42. Crotty Alexander LE, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. Myeloid cell sirtuin-1 expression does not alter host immune responses to gram-negative endotoxemia or gram-positive bacterial infection. PLOS ONE 2013;8:e84481 | PubMed
  43. Miller YI, Choi SH, Wiesner P, Bae YS. The SYK side of TLR4: Signalling mechanisms in response to LPS and minimally oxidized LDL. British journal of pharmacology. 2012;167:990-999 | PubMed
  44. Choi SH, Wiesner P, Almazan F, Kim J, Miller YI. Spleen tyrosine kinase regulates ap-1 dependent transcriptional response to minimally oxidized LDL. PLOS ONE. 2012;7:e32378 | PubMed
  45. Chang DC, Easterlin MC, Montesa C, Kaushal K, Wilson SE. Adoption of endovascular repair of abdominal aortic aneurysm in California: Lessons for future dissemination of surgical technology. Annals of vascular surgery. 2012;26:468-475 | PubMed
  46. Briley-Saebo KC, Nguyen TH, Saeboe AM, Cho YS, Ryu SK, Volkova ER, Dickson S, Leibundgut G, Wiesner P, Green S, Casanada F, Miller YI, Shaw W, Witztum JL, Fayad ZA, Tsimikas S. In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes. J Am Coll Cardiol. 2012;59:616-626 | PubMed
  47. Bhandari A, Crowe SE. Helicobacter pylori in gastric malignancies. Current gastroenterology reports. 2012;14:489-496 | PubMed
  48. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circulation research. 2011;108:235-248 | PubMed
  49. Maisel A, Xue Y, Shah K, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand IS, Ng L, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler NG, Anker SD. Increased 90-day mortality in patients with acute heart failure with elevated copeptin: Secondary results from the biomarkers in acute heart failure (bach) study. Circulation. Heart failure. 2011;4:613-620 | PubMed
  50. Xue Y, Chan J, Sakariya S, Maisel A. Biomarker-guided treatment of congestive heart failure. Congestive heart failure. 2010;16 Suppl 1:S62-67 | PubMed
  51. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa b and activator protein-1: Possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circulation research. 2010;107:56-65 | PubMed
  52. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: Macrophage binding and activation. The Journal of biological chemistry. 2010;285:32343-32351 | PubMed
  53. Di Somma S, Magrini L, Pittoni V, Marino R, Mastrantuono A, Ferri E, Ballarino P, Semplicini A, Bertazzoni G, Carpinteri G, Mule P, Pazzaglia M, Shah K, Maisel A, Clopton P. In-hospital percentage bnp reduction is highly predictive for adverse events in patients admitted for acute heart failure: The Italian red study. Critical care. 2010;14:R116 | PubMed

Topics of Resident Research Projects, 2016-2017

ResidentMentorTitle

Chang, Kay-Won

Daniel Blanchard, MD

Association of Right Ventricular Dyssynchrony in Patients with Heart Failure with Reduced Ejection Fraction Before and After Cardiac Resynchronization Therapy

Connelly, Alexander

Daniel Blanchard, MD; Timothy Fernandes, MD

H-FABP and ST-2 Levels, Hemodynamics, and Ultrasonographic Correlations Pre/Post-Pulmonary Endarterectomy in Pulmonary Hypertension

Dang, Yu-Xuan "John"

Luis Castellanos, MD

Observational Study to Evaluate Cardiac Rehabilitation Referral and Participation Rates of Patients from Diverse Racial and Ethnic Groups and Individuals from Rural Communities with Coronary Heart Disease

Devlin, Shannon

Heidi Young, MD

A Comparison of Pain Burden in Hospitalized Young Adult Cancer Patients to their Older Adult Counterpart

Duran, Jason

Barry Greenberg, MD

Hyperkalemia in Heart Failure with Reduced EF

Eng, Kevin

Rebecca Sell, MD

Etiology of In-Hospital Arrest Among Elderly Patients

Frankel, Brittany

Maripat Corr, MD

Can Thrombin activated RACPP be utilized to detect early rheumatoid arthritis?

Gabbai-Saldate, Paulette

Eric Roeland, MD

Understanding barriers to the appropriate implementation of palliative care in minority communities

Hsu, Simon

Joachim Ix, MD; Dena Rifkin, MD

Associations between eGFR and measures of pre-clinical peripheral arterial disease as detected by femoral artery ultrasound

Jiang, Hansi

Greg Seymann, MD

The impact of real-time performance dashboards on clinical practice: incentivizing through data display

Manu, Kavya

David Kunkel, MD

Characterizing motor disorders of the esophagus using the latest iteration of the Chicago classification including results of provocative testing and distensibility

Meserve, Joseph

Brigid Boland, MD

Risk for Clostridium Difficile Infection in Vedolizumab Treated Patients

Murtuza, Ayesha

Hatim Husain, MD

Analysis of Liquid Biopsies to Identify Resistance Mutations to Anti-EGFR Therapies in Lung Cancer

Nguyen, Andrew

David Krummen, MD

Outcomes of atrial fibrillation ablations

Nguyen, Nghia

Siddharth Singh, MD

Systematic review and network meta-analysis: Comparative effectiveness and safety of medical therapies for the treatment of mild-to-moderate ulcerative colitis

Nishimura, Marin

Jonathan Hsu, MD

Predictors of inpatient versus outpatient implantation of automatic cardioverter-defibrillators and associated adverse events

Patel, Nisha

Sandip Patel, MD

Incidence of thyroid function abnormalities in patients receiving immunotherapies for cancer treatment

Porter, Ashleigh

Ezra Cohen, MD

Genetic profiles in metastatic and recurrent head and neck cancers

Reinders, Megan

Rohit Loomba, MD

Risk of cirrhosis in first-degree relatives of patients with NAFLD cirrhosis

Rosen, Sheri

Jeremy Beitler, MD

Prognosis following in-hospital cardiac arrest among patients with cancer

Schroeder, Courtney

Annette von Drygalski, MD

Safety and benefits of therapeutic rock climbing in hemophilia patients with moderate to severe disease

Temple, John "Jack"​Arthur Kavanaugh, MDCorrelating clinical severity of psoriatic arthritis with the vectra DA, a multi-biomarker disease assay
​Truong, Alex​Robert El-Kareh, MDPredicting utility of thyroid function tests on hospitalized patients: a study of subsequent management changes
​Tyagi, Sanjeev​Jeremy Beitler, MDHyperchloremic Volume Resuscitation and Progression of Respiratory Failure in Patients with Sepsis and Respiratory Disease
​Yang, Jenny​Jeremy Beiter, MDVolume resuscitation for septic shock among patients with systolic heart failure
​Yee, Brittany​Tissa Hata, MDSteroid treatment of alopecia areata: a systematic review and meta-analysis