Antine E. Stenbit, MD, PhD

Dr. Stenbit earned her MD-PhD with honors from Albert Einstein College of Medicine, Bronx, NY, in 1998. She began her residency in the PSTP at UC San Diego in 1998 and completed her Pulmonary and Critical Care Medicine fellowship in 2005. After completing two years as a clinical instructor at UC San Diego, she is now an assistant professor at the University of South Carolina, where she continues to practice internal medicine. She is board certified in both pulmonary and internal medicine.

Selected Publications

Botstein, and E.W. Jones. 1992. The VPH1 gene encodes a 95- kDa integral membrane polypeptide required for the in vivo assembly and activity of the yeast vacuolar H+- ATPase. J. Biol. Chem. 267:14294-303.

Stenbit, A. 1993. Lysosomal associated membrane proteins LAMP-1 and LAMP-2. Einstein Quarterly 10:128-132.

Katz, E.B., A.E.Stenbit, K. Hatton, R. DePinho and M.J.Charron. 1995. Cardiac and adipose tissue abnormalities but not diabetes in GLUT4 deficient mice. Nature 377:151-155.

Stenbit, A.E., R. Burcelin, E.B. Katz, T.S. Tsao, N. Gautier, M.J. Charron and Y. Le Marchand-Brustel. 1996. Activation of a novel glucose transport system in muscles deficient in GLUT4. J. Clin. Invest. 98:629-634.

Katz, E.B., R. Buercelin, T.S. Tsao, A.E. Stenbit, and M.J. Charron. 1996. The metabolic consequences of altered glucose transporter expression in transgenic mice. J. Mol. Med. 74:639-652.

McCall, A.L., A. van Bueren, L. Haung, A. Stenbit, E. Celnick and M.J. Charron. 1997. Brain endothelium expresses insulin-regulatable glucose transporters. Brain Research 744:318-326.

Stenbit, A.E., T.S. Tsao, E.B. Katz, D. Geenan, R. Burcelin, F.C. Brosius, S.M. Factor and M.J. Charron. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Medicine 3: 1096-1101.

Tsao, T.S., A.E. Stenbit, J.Li, K.L. Houseknecht, J.R. Zierath, E.B. Katz, and M.J. Charron. 1997. Muscle-specific transgenic complementation of GLUT4-deficient mice: Effects on glucose but not lipid metabolism. J. Clin. Invest. 100:671-677.

Rossetti, L., A.E. Stenbit, L. Cheng, N. Barzali, E.B. Katz and M.J. Charron. (1997) Insulin resistance and altered glucose homeostasis in GLUT4 heterozygous knockout mice. J. Clin. Invest. 100:1831-1839.

Zierath, J.R., T.S. Tsao, A.E. Stenbit, J. Ryder, D. Galuska, and M.J. Charron. (1998) Restoration of hypoxia- stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation. J. Biol. Chem. 273:20910-20915.

Ryder, J.W., Y. Kawano, J. Rincon, T.S. Tsao, A.E.Stenbit, G.D. Holman, M.J. Charron, and J.R. Zierath. 1999. Biochemical characterization of a novel insulin-sensitive glucose transport system in GLUT4- null muscle. Biochemical J. 342:321-328.

Tsao,T.S., A.E. Stenbit, S.M. Factor, W. Chen, L. Rossetti, and M.J. Charron. 1999. Prevention of insulin resistance and diabetes in mice heterozygous for Glut4 ablation by transgenic complementation of Glut4 in skeletal muscle. Diabetes 48:775-782.

Stenbit, A.E., E.B. Katz, J.C. Chatham, D.L. Geenen, S.M. Factor, R.G. Weiss, T.S. Tsao, A. Malhotra, V.P. Checko, C. Ocampo, L.Jelicks, and M.J. Charron. 2000. GLUT4 null hearts preserve glucose metabolism and resist loss of function after ischemia. Am. J. Physiol. Heart Circ. Physiol. 279:H313-318.

Li,J., K.L. Houseknecht, A.E. Stenbit, E.B. Katz, and M.J. Charron. 2000. Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice. FASEB J. 14:1117-1125.

Li, J., T.S. Tsao, A.E. Stenbit, and M.J. Charron. Muscles lacking GLUT4 exhibit increased oxidative capacity. (submitted).

Tsao, T.S., J. Li, A.E. Stenbit, D. Galuska, J.E. Anderson, J.R. Zierath, and M.J. Charron. Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity Faseb J 15:958-96.

Stenbit, A.E., Duplain, H., Belke,‚Äč D.D, Holander, J.O., Xiong, D.,Summers-Torres, D., Froehner, S.C., Adams, M.E., and K.U. Knowlton. nNOS is primarily localized to the sarcoplasmic reticulum in cardiac myocytes and dependent on ?-syntrophin. J.Cell Science. submitted *denotes co-authors, each author contributed equally to this work

Stenbit, A. E. and K. J. Serio. Sepsis. In: Manual of Intensive Care Medicine (Fourth Edition) Richard S. Irwin and James M. Rippe (Eds.); Lippincott Williams and Wilkins; Division of Wolters Kluwer Health, Inc. (In Press).

Stenbit, A.E. Sarcoidosis. In: Manual of Clinical Problems in Pulmonary Medicine (Sixth Edition); R.A. Bordow, A.L. Ries, and T.A Morris (Eds.); Boston/Toronto/London: Little, Brown and Company (In Press).