Chester Drum, MD, PhD

Chester Drum

Dr. Drum received his MD from the University of Chicago in 2003. He received his PhD from the University of Chicago in 2002 for his studies of anthrax adenylyl cyclase exotoxin. He did his fellowship training in cardiology at Harvard. Dr. Drum has received the Harold Lamport Award for Best Dissertation in the Biological Sciences, University of Chicago, Division of the Biological Sciences and the Award for Difficult Structure Determination, Diffraction Methods Gordon Conference.

Selected Publications

Drum, C. L., Yan, S. Z., Bard, J., Shen, Y. Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., and Tang, W. J. (2002). "Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin." Nature, 415(6870), 396-402.

Drum, C. L., Shen, Y., Rice, P. A., Bohm, A., and Tang, W. J. (2001). "Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin." Acta Crystallogr D Biol Crystallogr, 57(Pt 12), 1881-4.

Drum, C. L., Yan, S. Z., Sarac, R., Mabuchi, Y., Beckingham, K., Bohm, A., Grabarek, Z., and Tang, W. J. (2000). "An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis." J Biol Chem, 275(46), 36334-40.

Tang, W. J., Yan, S., and Drum, C. L. (1998). "Class III adenylyl cyclases: regulation and underlying mechanisms." Adv Second Messenger Phosphoprotein Res, 32, 137-51

Benzinger, G. R., Drum, C. L., Chen, L. Q., Kallen, R. G. and Hanck, D. A. (1997). "Differences in the binding sites of two site-3 sodium channel toxins." Pflugers Arch, 434(6), 742-9.

Dias-Kadambi, B. L., Combs, K. A., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1996). "The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B." J Biol Chem, 271(39), 23828-35.

Dias-Kadambi, B. L., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1996). "Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel." J Biol Chem, 271(16), 9422-8.

Drum, C. L., Benzinger, G. R, Chen, L-Q., Kallen, R. G., Hanck, D. A. (1996). "Domain localization of isoform-specific determinants of site 3 toxin modification of voltage-gate Na channels." Biophys J, 70(2), A318

Kelso, G. J., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1996). "Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel." Biochemistry, 35(45), 14157-64.

Khera, P. K., Benzinger, G. R., Lipkind, G., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1995). "Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination." Biochemistry, 34(27), 8533-41.