Julio Anacleto Gutierrez, MS, MD

Dr. Gutierrez earned an undergraduate degree in Integrative Biology from University of California at Berkeley, a Master of Science from Columbia University and his MD from Mount Sinai School of Medicine in New York City. Dr. Gutierrez took the unusual path of undertaking a significant amount of research while at the same time completing his medical education uninterrupted. At Mount Sinai, Dr. Gutierrez worked with Dr. Andrea Branch studying the hepatitis C virus (HCV), using tools from bioinformatics, classical virology, molecular biology and translational research. The main focus of his research was identifying the natural history of the Alternate Reading Frame Protein in HCV, the humoral immune response to HCV proteins, and affinity purification of anti-HCV antibodies from ascitic fluid.

Dr. Gutierrez completed his training in Internal Medicine in 2009 at UCSD and is a Gastroenterology T32 Fellow until 2012. He joined the laboratory of Drs. Robert “Chip” Schooley and David Wyles where he continues to study HCV. He is the principal investigator of an IRB approved serum and tissue for chronic liver disease and co-investigator on two active grants. Currently, his research attempts to understand how vitamin D inhibits HCV in vitro. Additionally, he is conducting pilot studies of vitamin D supplementation measuring HCV viral kinetics. Another area of focus of Dr. Gutierrez’s research is to develop methods for ultra-deep sequencing in HCV. He is applying this technology to regions of HCV associated with hepatocellular carcinoma and resistance to direct acting antivirals against HCV. Dr. Gutierrez’s main clinical interest is in HCV and liver transplantation.

His awards and honors include the National Medical Fellowship, New York Academy of Medicine Louis Seaman Grant, Gelernt Award for Academic Excellence and Community Service, and Distinguished Fellow of the NACGF. He is a current co-investigator on a CFAR pilot project to characterize HCV mutations associated with hepatocellular carcinoma and a diversity supplement for Ms. Roxana Flores for ultra-deep sequencing of HCV mutations related to resistance of direct acting antivirals in HCV.

Selected Publications

Walewski, J.L., Gutierrez, J.A., Branch-Elliman, W., Stump, D.D., Keller, T.R., Rodriguez, A., Benson, G. & Branch, A.D. 2002, "Mutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions", RNA (New York, N.Y.), vol. 8, no. 5, pp. 557-571.

Branch, A.D., Stump, D.D., Gutierrez, J.A., Eng, F. & Walewski, J.L. 2005, "The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others", Seminars in liver disease, vol. 25, no. 1, pp. 105-117.

Lawal, A., Basler, C., Branch, A., Gutierrez, J., Schwartz, M. & Schiano, T.D. 2004, "Influenza vaccination in orthotopic liver transplant recipients: absence of post administration ALT elevation", American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 4, no. 11, pp. 1805-1809.

Schiano, T.D., Gutierrez, J.A., Walewski, J.L., Fiel, M.I., Cheng, B., Bodenheimer, H.,Jr, Thung, S.N., Chung, R.T., Schwartz, M.E., Bodian, C. & Branch, A.D. 2005, "Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors", Hepatology, vol. 42, no. 6, pp. 1420-1428.

Stanca, C.M., Bach, N., Krause, C., Tandon, N., Freni, M.A., Gutierrez, J.A., Bodian, C., Lopez, J., Berk, P.D., Bodenheimer, H.C.,Jr, Branch, A.D. & Odin, J.A. 2005, "Evaluation of fatigue in U.S. patients with primary biliary cirrhosis", The American Journal of Gastroenterology, vol. 100, no. 5, pp. 1104-1109.

Hytiroglou, P., Gutierrez, J.A., Freni, M., Odin, J.A., Stanca, C.M., Merati, S., Schiano, T.D., Branch, A.D. & Thung, S.N. 2009, "Recurrence of primary biliary cirrhosis and development of autoimmune hepatitis after liver transplant: A blind histologic study", Hepatology research : the official journal of the Japan Society of Hepatology, vol. 39, no. 6, pp. 577-584.

Childs, K.E., Fishman, S.L., Constable, C., Gutierrez, J.A., Wyatt, C.M., Dieterich, D.T., Mullen, M.P., & Branch, A.D. 2010, “Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users”, AIDS Res Hum Retroviruses. Vol. 8: pp. 855-9.

Gutierrez, J.A., Klepper, A., Garber, J., Walewski, J.L., Bateman, K., Khaitova, V., Syder, A., Tscherne, D.M., Gauthier, A., Jefferson, D., Rice, C.M., Schiano, T,D., & Branch, A.D. 2010, “Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid”, J Virol Methods. J Virol Methods. 2011 Jan;171(1):169-75.

Chang, T.L., Klepper, A., Ding, J., Garber, J., Rapista, A., Mosoian, A., Hubner, W., Gutierrez, J.A., Walewski, J., Abergel, J., Schiano, T. & Branch, A. 2010, "Human Peritoneal Macrophages From Ascitic Fluid Can be Infected by a Broad Range of Human Immunodeficiency Virus Type 1 Isolates", Journal of acquired immune deficiency syndromes. Vol. 53, no. 3, pp. 292-302.

Gutierrez J.A., Patton H., “HCV and ESRD.” Curent Hepatitis Reports. In Publication. June 2011.

Gutierrez, J.A., Jones, K.A., Fitzgerald, R.L., Branch, A.D., Schooley, R.T., & Wyles, D.L., “Vitamin D metabolites inhibit replication the hepatitis C virus”, 2011, In preparation for Hepatology.

Gutierrez J.A., Branch A.D., “Vitamin D and HCV.” Seminars in Liver Disease. Invited Manuscript in Preparation. August 2011.