Pradipta Ghosh, MD

Pradipta Ghosh

Dr. Ghosh obtained her medical degree from Christian Medical College, Vellore, in India. She graduated in 2000 as the Best Outgoing Student in Medicine, Surgery and Overall Best Outgoing Student adjudged by the Indian Medical Association on a nationwide ranking. She started her career in science as a research associate training under Dr. Stuart Kornfeld at Washington University in St. Louis, Missouri, in 2001 before beginning her internship and residency in internal medicine here at UC San Diego in 2003.

In 2008 she graduated from the Gastroenterology fellowship program and joined as an Assistant Professor on tenure track in the department of Medicine at UCSD. Ongoing work in her laboratory seeks to identify novel signal amplifiers/rheostats in a systematic and unbiased way using a three-pronged approach. Using these approaches her laboratory has already identified new rheostats with surprising functions during cellular processes such as membrane-trafficking, autophagy, survival, apoptosis, mitosis, differentiation and migration. Once systematically applied, these approaches have the real potential to revolutionize our understanding of signal transduction and the diverse biological processes and disease states that they control.

http://www.ghoshlab.ucsd.edu

Selected Publications

Do, H., Lee, W.S., Ghosh, P., Hollowell, T., Canfield, W. and Kornfeld, S: Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. J Biol Chem. 2002 Aug 16; 277(33):29737-44.

Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S: Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. J Biol Chem. 2002 May 24; 277(21):18477-82.

Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S: Autoinhibition of the

-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8072-7.

Ghosh, P.*, Doray, B.*, Griffith, J., Geuze, H.J. and Kornfeld, S. :Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science. 2002 Sep 6;297(5587):1700-3. (*Equal contribution 1st and 2nd authors)

Ghosh, P., Dahms, N.M. and Kornfeld, S: Mannose 6-phosphate receptors: new twists in the tale. Nature Rev Mol Cell Biol. 2003 Mar;4(3):202-12.

Ghosh, P. and Kornfeld, S.: Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem. 2003 Apr 18;278(16):14543-9.

Ghosh, P. and Kornfeld, S.: AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation. J Cell Biol. 2003 Mar 3;160(5):699-708. Epub 2003 Feb 25.

Ghosh, P., Griffith, J., Geuze, H.J. and Kornfeld, S. : Mammalian GGAs act together to sort mannose 6-phosphate receptors. J Cell Biol. 2003 Nov 24;163(4):755-66.

Ghosh, P. and Kornfeld, S.: GGA proteins: Key Players in Protein Sorting at the Trans-Golgi network. Eur. J Cell Biol, 2004, 83: (6)- 257-262.

Ghosh, P. and Kornfeld , S. : The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1. Arch Biochem Biophys. 2004 15;426(2):225-30.

Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. Peritoneal mice implicated in intestinal obstruction: report of a case and review of the

. J Clin Gastroenterol. 2006 May-Jun;40(5):427-30.

Ghosh, P, Santosa, A.C., Lin GY, Downs TM: De novo calcification of

and nodal metastases in prostate carcinoma. Prostate Cancer Prostatic Dis. 2006 May 9. (Nature Publishing Group).

Ghosh, P, Miyai, K and Chojkier, M. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14;13(6):960-3

Ghosh, P and Jung, B: Giant Paraesophageal Hernia Causing Compression Pulmonary Atelectasis: Starved for Air when Satiated with Food. J Gastroenterol and Hepat. 2007 Apr;22(4):595.

Ghosh, P., Olson, RK. and Harmon, G: Sugar Rush in the Colon: Why Incidental Findings on PET scan Justify Colonoscopy?, Amer J. Gastro, 2007 Nov;102(11):2609-10.

Ghosh, P and Kum, J. Mesenteric panniculitis and sclerosing mesenteritis: a continuum of inflammation fibrosis. Clin Gastroenterol Hepatol. 2007 May;5(5):A32.

Lee JK., Kum J., Ghosh, P. Gastrointestinal: Glycogenic acanthosis. J Gastroenterol Hepatol. 2007 Sep;22(9):1550.

Lee JK and Ghosh, P. Non-metastatic cancer of the colon associated with pyogenic

abscess. Am. J. Gastro, 2008 Mar; 103(3):798-9.

Lee, JK., Ghosh, P., McWhorter, V., Payne, M., Olson, RK., Ramamoorthy, S., Krinsky, ML., Carethers, JM. Evidence that rectal sarcomatoid carcinoma arises from tubulo-villous adenoma: Tumorigenesis caught in the act. World J Gastroenterology, 2008 Jul 21;14(27):4389-94.

Ghosh, P., Garcia-Marcos, M, Bornheimer, J. and Farquhar MG. Activation of Gai3 triggers cell migration via interaction with GIV. J. Cell Biol. 2008, Jul 28;182(2):381-93.

Garcia-Marcos, M*, Ghosh, P* and Farquhar, MG. GIV/Girdin is a non-receptor GEF for Gαi that features a unique molecular target for regulating Akt activity. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3178-83. * Equal contribution.

Park, F., Lee, J.K., Madduri, G. and Ghosh, P. Generalized Megaviscera of Lupus: Refractory Intestinal Pseudoobstruction, Ureterohydronephrosis and Megacholedochus. July 28, World J Gastroenterology, 2009.

Lee J.K., Carethers J.M., Ghosh, P, ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding. Gastroenterol Res Pract. 2009;2009:384506.

Ghosh, P., Carethers, J.M., Multiple "apple-core" lesions in chronic ischemic colitis: the great masquerader. Am J Gastroenterol. 2009 Nov;104(11):2870-2.

Garcia-Marcos, M., Ghosh, P., Ear, J. and Farquhar MG. A structural determinant that renders G{alpha}i sensitive to activation by GIV/Girdin is required to promote cell migration. J Biol Chem. 2010 Feb 15. [Epub ahead of print]. Highlighted in "Faculty of 1000" by Dr Danny Dhanasekharan (http://f1000.com/2267957).

Ghosh P., Beas, A., Bornheimer SJ., Garcia-Marcos M., Forry E.P., Johannson, C., Jung, B.H., Cabrera, BL., Carethers, J.M. and Farquhar MG. A Gαi-GIV molecular switch decides whether cells migrate or proliferate in response to growth factors. Mol Biol Cell., 2010 July 1;21(13):2338-2354. (Featured as Editor's Choice in Science Signaling AAAS- by Editor in Chief, Nancy Gough, entitled, "Move or Divide?" (http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/129/ec203) and also was selected for "Highlights in MBoC" and nominated for "Paper of the Year" by American Society of Cell Biology" (http://www.ascb.org/files/1008mboc.pdf).

Lee J.K., Bhargava, V., Mittal, R.K., Ghosh, P. Achalasia, Alcohol-stasis and Acute Necrotizing Esophagitis: Connecting the Dots. Digestive Dis. and Sci. 2011 Feb; 56 (2): 612-614.

Garcia-Marcos, M., Jung, B.H., Ear, J., Cabrera, B.L., Carethers, J.M., and Ghosh, P., Expression of GIV/Girdin, a Metastasis-Related Protein, Predicts Survival in Colorectal Cancer Patients. The FASEB J., 2011 Feb; 25 (2): 590-599. Featured in news article: http://www.newsrx.com/newsletters/Life-Science-Weekly/2011-03-15/25031520115457LS.html

Garcia-Marcos M., Ear, J., Farquhar, M. and Ghosh P. A GEF (GIV) and a GDI (AGS3) Regulate Autophagy by Balancing G protein Activity and Growth Factor Signals. Mol. Biol. Cell, 2011 Mar; 22 (5): 673-686.

Garcia-Marcos, M., Ghosh, P, and Farquhar, MG. Molecular Mechanism of a Novel Oncogenic Mutation in GNAO. Oncogene, 2011, Feb 14.

Lord, C., Bhandari, D., Menon, S., Ghassemian, M., Nycz, D., Hay, J., Ghosh, P., and Ferro-Novick, S. Sequential interactions with Sec23 control the direction of Vesicle traffic. In Press, Nature (Article), 2011. DOI: 10.1038/nature09969.

Ghosh, P., Garcia-Marcos, M., and Farquhar, M.G. GIV/Girdin is a Rheostat which Fine-tunes Growth Factor Signals During Tumor progression. In Press, Cell Adhesion and Migration, Vol 5, Issue 3. 2011.