Dr. Trey Ideker

​​​​​​Dr. Trey IdekerDr. Ideker is a Professor of Medicine at UC San Diego. He is the Director of the National Resource for Network Biology, the San Diego Center for Systems Biology,  and the Cancer Cell Map Initiative. He is a pioneer in using genome-scale measurements to construct network models of cellular processes and disease.

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 National Resource for Network Biology
San Diego Center for Systems Biology

About the Ideker Lab

Our goal is to develop a new type of medicine based on knowledge of the complete physical and functional wiring of the cell. ​We are developing new ways of mapping these wiring diagrams directly from genome-scale measurements (genomic, proteomic, and metabolomic) and for using these maps to translate the increasingly complex data gathered from patients to predict disease outcomes and develop better treatments.

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Featured News & Research

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. JP Shen, et. al., NatMethods  (Mar 2017). [PDF] [PubMed]  Press: GEN News HighlightsSD Union TribuneUCSD Health News, BioTechniques.

Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Hannah Carter, et. al., Cancer Discovery (Feb 2017). [PDF] [PubMed]

Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy
Michael Kramer, et. al., MolCell (Feb 2017). [PDF] [PubMed]

The Real Value of an Atlas, Trey Ideker. NIH Biomedical Informatics Blog (31 Oct 2016). [PDF]

Cancer Bioinformatics: A Disease of the Genome, Liz Harley. Frontline Genomics Magazine (Oct 2016). [PDF]

Follow up to Hannum, et al, MOLCELL 2013: Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA, Andy Gross, et. al., MOLCELL (2016). [PDF] 

Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems*. Mike Yu, et. al., Cell Systems (2016). [PDF] [*Cover Art]