Grant Support

Proyecto de Interés Publico D11I1029 (Ricardo Armisen and Kelly Frazer) 12/01/2012-12/01/2016    FONDEF Chile $677,248 ($88,400 for UCSD)"Incorporación de la secuenciación de ultima generación en el cuidado de los pacientes con cáncer". (FONDEF D11I1029 of public interest "Incorporating next generation sequencing into the care of cancer patients.")

Major Goals: Implement clinical targeted sequencing in Chile

SDCSB Seed Grant (Olivier Harismendy)

09/01/2012-08/31/2013 San Diego Center for Systems Biology $22,000 In vivo detection and genome-wide location analysis of DNA-adducts[1] Major Goals: develop a molecular method to directly located single strand DNA adducts in vivo 1R21CA155615 (Olivier Harismendy)

09/20/2011–07/31/2013 NIH/NCI  $128,570 Identification of Somatic Mutations in Rare Subclones of Solid Tumors Major Goals: Develop and validate an ultra-deep targeted sequencing assay for the clinical assessment of actionable somatic mutations in heterogeneous tumor samples. Role: PI 1U01HL107442-01 (Frazer, Kelly)

07/15/2011-06/30/2016 NIH/NHLBI $4,000,000 Regulatory Genomic Studies in a cohort of iPS cell derived cardiomyocytes Major Goals: Generation and use of IPSC derived cardiomyocytes from genotyped individuals as cellular models to investigate how human genetic variation influences the gene regulatory networks Involved In cardiac biology and disease. 1R21CA177519-01 (Olivier Harismendy)

09/03/2013 – 08/31/2016 NIH/NCI $435,000 In vivo detection and genome-wide location analysis of DNA-adducts Major Goals: Develop and Validate a molecular method to detect and locate DNA adduct genome-wide Role: PI (Barrett, PI)

9/1/2013 – 9/1/2014 $120,000 Sponsored Research Tanabe Research Labs, USA. Discovery of mRNA isoforms specifically expressed in clear cell renal cell carcinoma.