Activities

CLINICAL ACTIVITIES

INPATIENT/OUTPATIENT

The division’s clinical activity is primarily consultative assisting other medical and surgical divisions in the management of serious, complicated or unusual infections in children in both the inpatient and outpatient settings.

 

RESEARCH ACTIVITIES

John S. Bradley, MD is involved in Phase I through Phase IV clinical trials of antibacterials, antifungals, and non-HIV antivirals, and currently focuses on novel therapies for CA-MRSA and multi-drug resistant GNRs, incorporating pharmacokinetics/pharmacodynamics and Monte Carlo Simulation into clinical outcome assessment. He served on the FDA’s Anti-Infectives Advisory Drug Committee, and continues currently as an Advisor.  He is a participant in the Clinical Trials Transformation Initiative (FDA and Pharmaceutical Industry with Duke University) and the Critical Path Initiative to improve clinical trial design for antiinfectives in children.  He is a member of USCAST, an affiliate of EUCAST, to help determine antibiotic breakpoints based on in vitro susceptibility and animal model/human infection data with PK/PD modeling for both generic and branded antibiotics. He sits on the federal advisory committee for the Secretary HHS, the National Preparedness and Response Science Board to advise on issues of bioterrorism and natural/manmade disasters. He’s also a member of the CDC’s Botulism Bioterror Working Group. He is the editor-in-chief of the AAP’s Nelson’s Pediatric Antimicrobial Therapy with John Nelson, and is a member of the editorial boards of the Journal of the Pediatric Infectious Diseases Society and the Pediatric Infectious Disease Journal.

 

Grant Campbell, PhD studies the mechanisms that control autophagy in response to HIV-1 and M. tuberculosis infection by developing our understanding of how the endo/lysosomal system of macrophages is converted into providing a niche environment for controlled replication by M. tuberculosis and HIV-1. With a view to controlling infection, he is in the process of identifying pharmacological agents that induce autophagic flux and inhibit both HIV-1 and M. tuberculosis in macrophages. Through this work he has shown that the active metabolite of vitamin D induces autophagy and inhibits both HIV-1 and M. tuberculosis infection of macrophages.

 

Juan Chaparro, MD is completing a concurrent fellowship in medical informatics through the Division of Biomedical Informatics (DBMI) at UCSD. His primary research interests include the use of applied informatics and natural language processing to provide point-of-care clinical decision support. In collaboration with the Kawasaki Disease Research Center and the DBMI, he has aided in the creation of an NLP tool to identify the signs of Kawasaki Disease using physician documentation in the emergency department to improve early recognition of the disease. This tool is planning to be implemented into the Rady Epic EHR for further prospective studies. Dr. Chaparro has also collaborated with the development of a registry to identify high-risk patients eligible for Palivizumab prophylaxis and to ensure continued administration through the RSV season. He is also interested in improving physician documentation, and investigating the data integrity of the problem list. As a use-case he has created a best-practice alert to improve documentation of elevated BMIs in the pediatric population to aid in future registry creation and decision support. Dr. Chaparro is also involved in a multidisciplinary investigation into the microbiome/metabolome of patients with Cystic Fibrosis with a particular focus into how antibiotic treatment courses during acute exacerbations affect the microbiome/metabolome.

 

Alice Pong, MD has a keen interest in pediatric tuberculosis and participates in collaborative studies defining the cellular immune responses of children with acute and latent tuberculosis infections. Current research includes studying the efficacy of an interferon gamma assay to detect tuberculosis infection in children. She is also the hospital epidemiologist and is involved in clinical research studies related to infection control. She also directs the hospital antimicrobial stewardship program and manages initiatives related to stewardship.

 

Mark H. Sawyer, MD focuses his research activities on immunizations through a contract with the San Diego County Health and Human Services Agency Immunization Program. This program is involved in all aspects of immunization including immunization policy, assessment of immunization coverage levels, education of providers and the community about immunizations, promotion of San Diego’s computerized regional immunization information system, and focused research into ways to improve immunization delivery.

 

Kumud K. Singh, PhD lab is involved in understanding the unique role of innate immunity in HIV-1 neuropathogenesis and neurodegenerative diseases. His lab focuses on how complement activation in HIV-1 infected brain leads to immune complex deposition, neuroinflammatory cytokine response and HIV-1 associated neurocognitive disorders.  The Singh lab hypothesizes that complement activation is a common mechanism of neuroinflammation and CNS impairment due to an infection (HIV), autoimmunity (multiple sclerosis) and aging related consequences (Alzheimer’s disease).

 

Stephen A. Spector, MD has sought to discover novel approaches for the detection, treatment, prevention and immunopathogenesis of HIV and human cytomegalovirus (CMV). His laboratory has been involved with HIV/AIDS research since the beginning of the epidemic. Current ongoing research examines HIV pathogenesis with a particular emphasis on host-virus interactions, and the associations of host genetic variants on HIV diseases progression and HIV-related diseases including CNS impairment in children and adults. The laboratory’s interest in the identification of host factors that affect HIV pathogenesis led to the novel finding that during permissive infection, HIV down-regulates autophagy to promote its own replication, and the induction of autophagy (using mTOR inhibitors as well as vitamin D3) inhibits HIV replication. The laboratory has also identified specific host genetic variants that are associated with mother-to-child transmission, HIV disease progression, and antiretroviral pharmacokinetics and adverse effects. This research has led to his laboratory examining the association of host factors that control HIV replication with the goal of identifying novel strategies to eradicate HIV from those infected. Dr. Spector also directs the Mother-Child-Adolescent HIV Program that provides care, social service, case management and research opportunities for HIV-infected and affected women, pregnant women, youth and children. 

 

TEACHING ACTIVITIES

The Division of Infectious Diseases provides care and on-service direct teaching of students, pediatric and pharmacy residents, and fellows in the diagnosis and management of pediatric infectious diseases. The ID service begins rounds each day in microbiology, where cultures, stains and histology are reviewed, followed by radiology rounds and ward rounds, and visits to the Emergency Department to provide a superb hands-on teaching experience.

 

John S. Bradley, MD

  • Lecturer, RCHSD Noon Conferences
  • Inpatient rounds and weekly case conferences, Pediatric Infectious Diseases

     

    Christopher R. Cannavino, MD

  • Lecturer, RCHSD Noon Conferences
  • Inpatient rounds and weekly case conferences, Pediatric Infectious Diseases

     

    Juan Chaparro, MD

  • Inpatient rounds and weekly case conferences, Pediatric Infectious Diseases
  • Lecturer, RCHSD Noon Conferences

     

    Alice Pong, MD

  • Lecturer, RCHSD Noon Conferences
  • Inpatient rounds and weekly case conferences, Pediatric Infectious Diseases

     

     Mark Sawyer, MD

  • Pediatric Residency Director
  • Directs a focused curriculum on immunizations for primary care residents
  • Lecturer, Pediatric Infectious Diseases
  • Inpatient rounds and weekly case conferences, Pediatric Infectious Diseases
  • ISP student advisor

     

    Kumud K Singh, PhD

  • Instructor, Problem Based Learning Curriculum for First and Second year Medical Undergraduate Students (Clinical Foundations I SOMC 224ABC
  • Instructor, Pediatrics Pharmacogenetics and Pharmacogenomics (PHAR 235/ BIOM235)
  • Organizer, Children Health Education and Research Seminars (CHERS)

     

    Stephen A. Spector, MD

  • Instructor, Medical Microbiology for second-year medical students
  • Instructor, Medical Microbiology Laboratory
  • Lecturer, Pediatric Infectious Diseases
  • Lecturer Infectious Disease Fellowship series
  • Lecturer Military International HIV Training Program
  • Inpatient rounds and weekly case conferences, Pediatric Infectious Diseases
  • Member of PhD committees for biomedical sciences students
  • ISP student advisor