Lawrence (Lance) S. Prince, MD, PhD, is a board-certified pediatrician and neonatal-perinatal medicine specialist and Associate Professor of Pediatrics at UC San Diego. Dr. Prince is the Division Chief of Neonatology at the University of California, San Diego and Rady Children’s Hospital, San Diego. He has a particular clinical interest in managing and treating neonatal lung diseases, especially bronchopulmonary dysplasia (BPD) in babies born extremely preterm. Dr. Prince’s research interests include the molecular and cellular mechanisms controlling lung development and the maturation of the fetal and neonatal immune systems.
As part of collaborations with other investigators at UC San Diego, Dr. Prince’s research team is developing new strategies for preventing lung injury and promoting lung regeneration and growth. Prior to joining UC San Diego faculty, Dr. Prince was Associate Professor of Pediatrics and Cell and Developmental Biology at Vanderbilt University.
Lab Focus: Mechanisms of Lung Disease in Preterm Infants
The Prince Lab studies mechanisms of lung disease in patients that develop bronchopulmonary dysplasia, inflammatory mediators that inhibit normal lung development. By using both patient-based translational studies and experimental approaches, we are investigating the basic molecular and cellular mechanisms of how these environmental signals interfere with normal developmental programs and pathways.
Ongoing projects in the lab study:
- The development of the lung innate immune system.
- How inflammatory signaling in the fetal lung disrupts epithelial-mesenchymal interactions during airway branching morphogenesis.
- The role of fetal lung macrophages in mediating the innate immune response in developing lungs.
Studying lung macrophages obtained from preterm infants allows us to better understand the disease mechanisms in patients with lung inflammation. More detailed approaches to phenotyping infants with chronic lung disease will help better characterize and quantify disease severity. To interrogate disease-based mechanisms in mice, we have developed and used a murine chorioamnionitis model as well as a saccular stage lung explant system that more closely models the stages of lung development relevant to extremely preterm infants. By using modern transgenic technology and sophisticated imaging approaches to study lung development and disease, we hope to better understand the molecular mechanisms of both normal epithelial-mesenchymal interactions and how inflammation causes human lung disease.
Postdoctoral and Job Opportunities in Prince Laboratory
Please send relevant CVs and cover letters to Denisse Sanchez to be reviewed at Dr. Prince's discretion should there be a fitting opportunity. Thank you so much for your interest!!
Denisse Sanchez – Administrative Assistant
Staff Res. Assoc. II
Inside New location at BRF Building
Current Location at Leichtag Building Outside New location at BRF Building