Research

James Hagood, MD, the Division Chief, studies the molecular regulation of fibroblast phenotypes in pulmonary fibrotic disease and lung alveolarization. He also studies the roles and regulation of Thy-1, a critical modulator of cellular phenotype, and epigenetic/epigenomic alterations in lung development and disease, and targeted therapy for diffuse lung diseases.

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Dr. Hagood's publications on PubMed

Gabriel Haddad, MD, studies the role of ion channels in nerve cells in a low O2 environment. He is also interested in the genetics of susceptibility or tolerance to low or high O2 and the role of gene expression in excitable tissues. He also studies obstructive sleep apnea and the role of hypoxia and hypercapnia on growth and development.

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Dr. Haddad's publications on PubMed 

Kathryn Akong, MD, PhD, completed fellowship training in June, 2011, and joined the faculty as Assistant Professor. She collaborates closely with Dr. Victor Nizet (Pharmacology and Drug Discovery), with whom she studies the role of neutrophil extracellular traps in lung host defense against infection.

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Priti Azad, PhD, studies mechanisms by which intermittent (e.g., obstructive sleep apnea and sickle cell anemia) and constant hypoxia (e.g., asthma) lead to cell injury and morbidity or adaptation and survival using Drosophila as well as cell culture model systems.

Robert Douglas, PhD analyzes the role of reactive oxygen species (ROS) and the immune system in hypoxia- and hypercapnia-induced neuronal and cardiovascular injury and their developmental sequelae.

Dr. Douglas' publications on PubMed

Xiang Gu, PhD studies the effect of chronic elevated CO2 on excitability of mouse neurons and the effect of hypoxia on gating properties of BK channels of inner membrane of mitochondria.

Dr. Gu's publications on PubMed

He Huang, PhD systematically screens for genes that are critical or necessary for recovery from oxygen deprivation in genetic models

Daniel Lesser, MD, is involved in clinical research investigating the role of sleep disordered breathing in metabolic disease.

Mark Pian, MD conducts translational and clinical research in cystic fibrosis. He is also the Co-Principal Investigator of the UCSD Cystic Fibrosis Foundation Therapeutic Development Center.

Dr. Pian's publications on PubMed

Paul Quinton, PhD investigates the effects of the genetic defects in fluid and electrolyte transport in cystic fibrosis on pathophysiology in the airways, intestine, and sweat glands in cystic fibrosis and related diseases.

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Dr. Quinton's publications on PubMed

Mindy Ross, MD, MBA completed fellowship training in June 2013 and is currently on a training grant scholar for research in clinical informatics, focusing on electronic health record and asthma management optimization.

Julie Ryu, MD studies innovative methodologies including remote monitoring of asthma management and bronchoscopy as a potential tool to diagnose asthma in children.

Dr. Ryu's publications on PubMed

A.K.M. Shamsuddin, PhD studies β-adrenergic sweat stimulation, sweat diagnostic testing and electrolyte transport across normal and cystic fibrosis sweat gland and native small and large airway (pigs and humans) epithelia.

Dr. Shamsuddin's publications on PubMed

Simon Wong, PhD studies novel therapeutic modalities and therapeutic targeting in animal models of lung fibrosis, as well as possible therapeutic roles of microvesicles in lung fibrosis.

Dr. Wong's publications in PubMed

Jin Xue, MD, PhD studies the genetic and molecular basis of sodium hydrogen exchanger isoform 1 (NHE1)-mediated cardiac injury.

Dr. Xue's publications on PubMed

Hang Yao, PhD studies the cellular and molecular mechanisms of penumbral cell death in focal cerebral ischemia.

Dr. Yao's publications on PubMed

Ning Yang, MD, PhD investigates the role of HCO3- in normal mucus formation/release and how to correct the abnormal mucus in cystic fibrosis in the intestine and other associated organs.

Huiwen Zhao, PhD, studies mechanisms of hypoxia adaptation using induced pluripotent stem cells-derived neurons obtained from patients with chronic mountain sickness

Dan Zhou, PhD studies the genetic and molecular mechanisms underlying hypoxia and hyperoxia adaptation and tolerance.

Dr. Zhou's publications on PubMed

POST-DOCTORAL FELLOWS RESEARCH ACTIVITIES

Mateja Cernelc-Kohan, MD
Postdoctoral Research Project: Role of extracellular microvesicles in Pulmonary Fibrosis

Matthew Pamenter, PhD
Postdoctoral Research Project: Understanding the role of innate immunity in ischemic neurodegeneration in the penumbral region

Tsering Stobdan, PhD
Postdoctoral Research Project: Hypoxic/high altitude genetic adaptation