Research

Seema S. Aceves, MD, PhD
  • NIH funded study (R01) on the mechanisms of tissue remodeling in eosinophilic esophagitis (EoE) (the role of pro-inflammatory and pro-fibrotic molecules), diagnosis (biomarker discovery), and treatment options and their effects on disease complications such as esophageal remodeling 
  • DOD funded study of the genetics of food allergic EoE
  • Executive Council member, The International Gastrointestinal Eosinophil Research Network
  • Editorial Board of Journal of Allergy and Clinical Immunology
  • New Grant: AAAAI/APFED HOPE Pilot Project in Eosinophilic Diseases
John F. Bastian, MD
  • Difficult asthma
  • Immunodeficiency disorders
Jane C. Burns, MD
  • The pathophysiology, immunology, diagnosis, etiology, treatment, genetics, epidemiology and history of Kawasaki disease 
  • A multicenter, randomized placebo-controlled clinical trial of infliximab plus IVIG for primary treatment of Kawasaki disease
  • Call-back study of adolescents and young adults with a history of Kawasaki disease in childhood
Johanna Chang, MD
  • Pediatric Joint Ultrasound
  • Coinvestigator on several CARRA clinical trials
Alessandra M. Franco, MD, PhD
  • T-cell repertoire in Kawasaki disease
  • Biological function of IVIG therapy
  • Immune-regulation in infants and young children
  • Cytotoxic T cell biology
  • Carbohydrate T cell recognition 
  • Designer glycopeptides containing tumor-associated carbohydrate antigens as vaccines for prevention/treatment of epithelial cancer
  Hal M. Hoffman, MD
  • Role of innate immunity and IL-1 therapy in autoinflammatory disorders 
  • Characterization of cryopyrin inflammasome function using a number of experimental models, including in vitro cell lines, ex vivo monocytes and genetically modified mice 
  • Genetic basis of rare inherited disorders including congenital diarrheas, rare urticarial, and immunodeficiency, and autoinflammatory disorders
  • Inflammatory mechanisms involved in periodic fever disorders of childhood
Anthony A. Horner, MD
  • Characterization of the molecular content and immunological activities of sterile house dust extracts to better define the immunomodulatory role living environments have on the genesis of allergic diseases
  • Translational studies to determine if house dust extract bioactivities are predictive of the intrinsic allergic risk associated with being raised in their homes of origin
  • Treatment of allergic diseases with toll-like receptor ligands and other immune-modulatory molecules
  • Development of a new generation multiplex assay to detect IgE to peanut alergens and to measure their binding affinities (Collaboration with Genalyte)
Stephanie Leonard, MD
  • Principle Investigator of Clinical trial at RCHSD site, for novel treatments of peanut allegy
Karin Peterson, MD, PhD
  • Immundeficiency disorders
Robert M. Sheets, MD
  • Clinical trials of new treatments for pediatric rheumatologic diseases including the TREAT study
Chisato Shimizu, MD
  • Genetics and molecular pathogenesis of Kawasaki disease
Ilona S. Szer, MD
  • Conducts several clinical trials of new treatments for juvenile arthritis and pediatric rheumatologic diseases 
  • As member of CARRA, Dr. Szer participates in the evaluation and implementation of multicenter studies in Pediatric Rheumatology
  • Chair of DSMB for two current trials