​​​​​​​​​​​​​​​​Kyle J. Gaulton, PhD

Pediatric Diabetes Research Center (PDRC)

Assistant Professor, UCSD Department of Pediatrics               

phone: 858-822-3640 
e-mail: kgaulton@ucsd.edu

Gaulton Lab website

BIOGRAPHY

Dr. Gaulton joined the Pediatric Diabetes Research Center in January 2016.  He has a BAS in computer science from the University of Pennsylvania and PhD in genetics and molecular biology from the University of North Carolina at Chapel Hill. Dr. Gaulton did post-doctoral training in human genetics, genomics and epigenetics at the University of Oxford and Stanford University.

RESEARCH INTERESTS

Dr. Gaulton studies how genetic risk contributes to the development of diabetes. Using computational and molecular genetics, the Gaulton lab addresses contemporary questions about human genetic variation and its effect on genome function and diabetes risk. His research will help identify novel strategies for preserving beta cells in patients at risk for type 1 diabetes. 

RECENT PUBLICATIONS

Pasquali  L*, Gaulton  KJ*, Rodriguez-Segui  S*, Mularoni  L, Miguel-Escalada  I, Akerman  I, Tena JJ, Gomez-Marin C, van de Bunt M, Ponsa-Cobas  J, Moran I, Castro N, Nammo T, Cebola I, Garcia-Hurtado  J, Maestro MA, Pattou F, Piemonti L, Berny T, Gloyn A, Ravassard P, Skarmeta JL, Muller F, McCarthy MI, Ferrer J.  Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated  variants. Nature Genetics. 46(2): 136-43. 2014. (*co-first authors)

Mahajan A*, Jin Go M*, Zhang W*, Below JE*, Gaulton KJ*, et al.  Genome-wide  trans-ethnic  meta-analysis reveals novel insights into the genetic architecture of type 2-diabetes susceptibility. Nature Genetics. 46(3): 234-44. 2014. (*co-first authors)

Gaulton KJ, Flannick J, Fuchsberger C. Whole genome and exome sequencing of type 2 diabetes. Genetics in Diabetes, Type 2 Diabetes and Related Traits. Front Diabetes. Basel, Karger, 2014, vol 23, pp 29-41.

Chambers JC, Abbott J, Zhang W, Turro E, Scott WR, Tan S, Loh M, Lehne B, O'Reilly P, Gaulton KJ, et al. The South Asian Genome. PLOS One. 9(8): e102645. 2014.

Fogarty M, Swarooparani V, Cannon ME, Gaulton KJ, Mohlke KL. Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus. PLOS Genetics. 10(9): e1004633.2014.

Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, Almedia M, Tanaka T, Perry JR, Gaulton KJ, et al. Whole genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Human Molecular Genetics. 2014 Nov 6

McCarthy D, Humburg P, Kanapin A, Rivas MA, Gaulton KJ, WGS500 Consortium, Cazier J, Donnelly P. Choice of transcripts and software has a large effect on variant annotation. Genome Medicine. 6(3): 26. 2014.

Lange LA, Hu Y, Zhang H, Xue C, Schmidt E, Tang Z, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li K, Flannick J, Zhang J, Fuchsberger C, Gaulton K, et al. Whole-exome sequencing identifies rare and low frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics. 94(2): 233-245. 2014.​

Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N, Im HK, Cingolani P, Flannick J, Fontanillas P, Fuchsberger C, Gaulton KJ, et al. Identification and functional characterization of G6PC2 coding variants influencing glycemic traits defines effector transcript at the G6PC2-ABCB11 locus. PLOS Genetics. 2015 Jan 27.​

Gaulton KJ*, Ferreira T*, Lee Y*, Raimondo A*, Magi R*, Reschen M, [ … ], Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP.Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.Nature Genetics. 2015. doi: 10.1038/ng.3437. (*co-first authors)

Reschen M*, Gaulton KJ*, Salous AK, Lin DA, Soilleux E, Smyth SS, Morris AJ, O'Callaghan C. Lipid-induced epigenomicchangesin human macrophagesidentify a coronary artery disease associated ​variant that regulates PPAP2BexpressionthroughalteredC/EBP-betabinding. PLOS Genetics.2015 Apr 2;11(4):e1005061(*co-first authors)

​van de Bunt M, Fox JE, Dai X, Barrett A, Grey C, Li L, Bennett A, Johnson PR, Rajotte RV, Gaulton KJ, Dermitzakis ET, MacDonald PE, McCarthy MI, Gloyn AL. Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycemic traits to their downstream effectors. PLOS Genetics. 11(12):e1005694. 2015.

Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Gaulton KJ, et al. Functional regulatory variants at the GALNT2 human high-density lipoprotein cholesterol locus. Am J Hum Genet. 97(6): 801-815. 2015.

Horikoshi M, Magi R, van de Bunt M, Surakka I, Sarin A, Mahajan A, Marullo L, Thorleifsson G, Hagg S, Hottenga J, Ladenvall C, Ried JS, Winkler TW, Willems SM, Tsernikova N, Esko T, Beekman M, Nelson CP, Willenborg C, Wiltshire S, Ferreira T, Fernandez J, Gaulton KJ, et al. Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation. PLOS Genetics. 11(7):e1005230. 2015.

Moutsianas L, Agarwala V, Fuchsberger C, Flannick J, Rivas M, Gaulton KJ, the GoT2D Consortium, McVean G, Boehnke M, Altshuler D, McCarthy MI. The power of gene-based rare variant methods to detect disease associated variation and test hypotheses about complex disease. PLOS Genetics. 11(4):e1005165. 2015