Wenxian Fu, PhD

Pediatric Diabetes Research Center (PDRC)

Assistant Professor, UCSD Department of Pediatrics               

phone: 858-246-0022
e-mail: w3fu@ucsd.edu

Fu Lab website​

BIOGRAPHY

Dr. Fu received his Ph.D. in Immunology at Peking University, China, where he studied the role of chemokines in immune cell migration and maturation. Dr. Fu did his postdoctoral training first at Joslin Diabetes Center and then at the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, where his research has focused on the pathogenesis of autoimmune type 1 diabetes and the molecular mechanisms of Foxp3+ regulatory T cells.

RESEARCH INTERESTS

Dr. Fu’s research focuses on the immune regulatory mechanisms that lead to type 1 diabetes with the goal of discovering new preventive and therapeutic strategies.  His lab is also exploring new imaging methods for predicting the risk of developing type 1 diabetes before patients are diagnosed with the disease.

RECENT PUBLICATIONS

Fu W, Wojtkiewicz G, Weissleder R, Benoist C and Mathis D. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nature Immunology. 2012. 13: 361-368. (Journal Cover)  

Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D and Benoist C. A multiply redundant genetic switch ‘locks in’ the transcriptional signature of T regulatory cells. Nature Immunology. 2012. 13: 972–980.

Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik D, Mathis D, Hotamisligil G. ATF6-dependent restoration of defective beta cell UPR with TUDCA protects mice against type 1 diabetes. Science Translational Medicine. 2013. 5:211ra156.

Gutierrez D, Fu W, Schonefeldt S, Feyerabend T, Ortiz-Lopez A, Lampi Y, Liston A, Mathis D, Rodewald H. Type 1 Diabetes in NOD Mice is Unaffected by Mast Cell Deficiency. Diabetes (online advanced publication).​   

Fu W, Farache J, Clardy S, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha R, Benoist C,Mathis D. Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages andβ cells. eLife. 2014. 10.7554/eLife.04631. [Journal cover; highlighted in eLife. 2014;3:e05720; NEngl J Med. 2015. 372: 778-80]