Lab Staff

Dr. Ariel Feldstein

 

 



Dr. Ariel Feldstein




            After medical school at the University of Buenos Aires, Argentina, Dr. Feldstein completed his pediatric residency, gastroenterology fellowship and postdoctoral research fellowship in liver pathobiology at the Mayo Clinic in 2004. Before coming to UCSD, he was the Director of Research for the Pediatric Institute at the Cleveland Clinic in Cleveland, Ohio. In addition to serving as Pediatric Gastroenterology Division Chief, he is currently Professor of Pediatrics, at the University of California, San Diego (UCSD).

CLINICAL EXPERTISE

        Dr. Feldstein's clinical expertise is centered on the field of pediatric hepatology. He currently follows one of the largest populations of children with fatty liver disease, autoimmune hepatitis and primary sclerosing cholangitis.

RESEARCH INTERESTS

    Ariel Feldstein, M.D. is regarded as a leading physician scientist in the field of Pediatric Hepatology, having pioneered the development of non-invasive tests for assessing liver damage in patients with liver disease and holds various patents for these markers. Dr. Feldstein's research is focused on dissecting the biochemical pathways of cell death triggers caused by the over-accumulation of fatty acids and other lipids in the liver and other organs, which may play an important role in disease processes such as obesity-associated liver disease (nonalcoholic steatohepatitis or NASH), and type 2 diabetes. A second objective of the lab is to better understand the events that link an excessive accumulation of lipids in the liver (steatosis) to liver injury, fibrosis and carcinogenesis.


Project Scientist



Akiko Eguchi, PhD​



Akiko Eguchi, PhD​




Akiko Eguchi, PhD​ Aki comes from Japan. She received her Bachelor of Engineering, and her Master's and Doctoral Degrees (medicine) from Osaka University in Japan. During her postdoctoral training in Japan and in the USA (UCSD, Dr. Steven Dowdy laboratory), she developed gene delivery systems and published these results in high-impact peer-reviewed journals, including Nature Biotechnology (2009). Her goal is to discover novel drugs for human diseases using her breadth of knowledge and research skills in molecular biology, biochemistry, virology, cell and animal biology. She believes that detailed observation, scientific sense, analysis and communication can overcome project difficulties and achieve success. ​

Aki's projects: Development of new Biomarkers focusing on extracellular vesicles and therapeutic targets using nano technologies for early stage liver diseases and Prediabetes. I also have concurrent projects involving collaborations with academia and industry relating to diseases of the liver.

Aki's recent awards: Research Scholars program in liver disease (Gilead Sciences), Pilot project grants (Southern California Research Center for ALPD and Cirrhosis), Young investigator awards (International Conference on biomaterials science, International symposium on the cells of the hepatic sinusoid, EASL, etc.).

 

Post-Doctoral Fellows

 

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Susanne studied Nutritional Sciences at the Martin-Luther University Halle-Wittenberg in Germany where she graduated in 2009. Afterward, she did postgraduate study abroad at the University of Auckland in New Zealand in Biomedical Science​s for 8 months. From 2010 to 2015, Susanne was working as a PhD student in the lab of Prof. Wieland Kiess at the Center for Pediatric Research at the University of Leipzig in Germany where she was studying non-alcoholic fatty liver disease in children and the role of NAD metabolism in hepatocellular carcinoma. In July 2015, Susanne defended her PhD thesis in Biochemistry at the University of Leipzig, Germany. A research scholarship from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) enables her to work as a Postdoc Fellow in the lab of Prof. Feldstein since February 2016. Susanne will study the role of oxidized linoleic acid metabolites (OXLAMs) in the development of liver injury in mice and will investigate the underlying mechanism how OXLAMs induce mitochondrial dysfunction. In another project, Susanne will investigate the effects of a novel ASK1 inhibitor in genetic and dietary models of steatohepatitis.​

 


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Carolina Jimenez Calvente​, PhD​



Carolina completed her Masters degree in Pharmacy at the University of Granada (South Spain) in 2008. Then she started to work as a pharmacist for a pharmaceutical brand, Gicofa, until 2009. As she was always passionate about science, she applied for a visiting fellowship to participate in a research project at the Institute of Ophthalmology from the Johannes Guttenberg University (Mainz, Germany). Nine months later, Carolina was awarded with a 3-years PhD fellowship from the DFG to work on therapeutic RNAs in liver fibrosis at the Institute of Translational Immunology under the supervision of Prof Schuppan until March of 2015. During those three years she also actively participated in the Immunotherapy Graduate School of the Johannes Gutenberg University. 

Currently, Carolina is appointed as a Postdoctoral employee in the lab of Prof Ariel Feldstein within the Department of Pediatrics at UCSD.  Her project focus is​ to determine the role of synthetic RNAs in NASH and fibrosis. ​

 

 Visiting Scholars




Masahiko Tameda

Masa is joining us from Japan where he collborated with Aki




 

​Lab Manager / Researcher


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Casey Johnson

This man needs no introduction...  

 

 



Student Volunteers

 

Hana A Del-Pilar, UCSD undergrad

Sophia Chen, summer intern from Torrey Pines High School

Mei Fu Lee, recent UCSD grad

Serena Lin, UCSD undergrad 

 

​​Feldstein Lab Alumni (UCSD)...where are they now?


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David "Slappy" Kneiber 

UCSD class of 2016.  Off to med school at Washington University in St. Louis...  

This guy crushed the MCAT's, if you need some pointers, give him a call.



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Davide Povero, Ph.D.

Davide is now working for Jecure Therapeutics...  E un amante del gatto.




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​​​Alex Wree, M.D., Ph.D.

Alex is now running his own lab back in Germany and was lucky enough to get Euge to join him.

 


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Fernando "Nando" Alegre

Our Extremeñho compadre has returned to España to continue his studies.

 

 


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Hirokazu Yamashita

Hiro has returned to medical school in Yokohama and still testing the limits of human caffiene consumption. 

 


Ryota "Tony" Nakamura

Tony has returned to Japan to continue with ​medical school.  Rumor has it he never sleeps.


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Kathryn Smith, M.D.

Liver transplantation fellowship at UCSF and paying $2000 for a studio apartment.

 

 


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Daphne Say, M.D.

Presently working at UC Davis Medical Center and enjoying the aroma of cows. 

 

  

​​Leila Bagheri 

Leila will be starting school at UC Berkeley in the fall of 2017.


Milos Lazic, Ph.D.

Mighty, mighty Milos is now at Jecure Therapeutics...  he's still a donkey cheese connoisseur.​


Eugenia Inzaugarat​, Ph.D.

Euge is now in Aachen, Germany working in the Wree Lab and discovering snow.


Dimitru Sirbu

In between dodging tornadoes, Dimitry attends the University of Oklahoma in pursuit of a Pharm.D.​


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Roia Katebian, M.D.


Roia is in Chicago trying not to freeze to death and hammering through her residency.

 

 

  

Nadia Panera, Ph.D.

Nadia is back in Rome at Osp. Pediatrico Bambino Gesù​ working as a post-doc.


Lucas​ de Araujo Horcel​​​

Lucas has returned to Brazil to continue his studies and watch the Olympics.


Brian Mak

Off to college...


Andy Bodnar

Andy (a.k.a. Curly) is a UCSD undergrad.


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Keaton Blazer

Still at Canyon Crest Academy High School, but now much wiser.

 

 

 

Collaborators

Meaningful collaboration is one of the central tenets of the Feldstein lab ethos. We are always looking for new and interesting ways to apply our knowledge and expertise. If you wish to embark on a scientific collaboration with a dynamic and award-winning laboratory, please contact Casey Johnson, Lab Manager at cdj002@ucsd.edu.

We have established collaborations with the following researchers:

Dr. Leon Adams (​University of Western Australia)

Dr. Naim Alkhouri (Cleveland clinic, USA)

Dr. Marco Arrese (Universidad Catolica de Chile, Santiago, Chile) ​

Dr. Ali Canbay (Essen Uni, Germany)

Dr. Sonia Caprio (Yale Uni​versity, USA)

Dr. Lawrence Goldstein (UCSD)

Dr. Stanley Hazen (Cleveland Clinic, USA)

Dr. Harold Hoffman (UCSD) 

Dr. Michael Karin (UCSD)

Dr. Irina Kirpich (​University of Louisville) 

Dr. Craig McClain (University of Louisville)

Dr. Yukio Nagasaki (Tsukuba University, Japan) 

Dr. Valerio Nobili (Bambin Gesu', Italy)

Dr. Maurizio Parola (Torino Uni, Italy)

Dr. Hemal Patel (UCSD, VA hospital)

Dr. Susan Phillips (UCSD)

Dr. Christopher Ramsden (NIH / NIAAA)

Dr. Dorothy Sears (UCSD) 

Dr. Ekihiro Seki (Cedars-Sinai Medical Center)

Dr. Hidekazu Tsukamoto (USC)

Dr. Vallon Volker (UCSD, VA hospital) 

Dr. Claudia Zein (Cleveland clinic, USA)​