Selected Recent Publications


Azad, Priti and R.C. Woodruff, 2010 Increase in viability due to new beneficial mutations in Drosophila melanogaster: Support for the Dobzhansky and Spassky assay. Genetica. 2010 Feb;138(2):251-63.

Azad P, Zhou D, Russo E, Haddad GG. 2009 Distinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster. PLoS ONE 4(4): e5371.

Azad P, Haddad GG, 2009 Survival in Acute and Severe Low O2 Environment. Annals of the New York Academy of Sciences 1177(1): 39-47.

Gu, X.Q., Siemen, D., Parvez, S., Cheng, Y., Xue, J., Zhou, D., Sun, X., Jonas, E.A., and Haddad, G.G. (2007) Hypoxia increases BK channel activity in the inner mitochondrial membrane. Biochem Biophys Res Commun. 358:311-316.

Huang H and Haddad GG. Drosophila dMRP4 regulates responsiveness to O2 deprivation and
development under hypoxia. Physiol Genomics 29: 260-266, 2007).

Ryu J; Vicencio AG, Yeager M, Kashgarian M, Haddad GG, Eickelberg O. Differential expression of Matrix Metalloproteinases and their inhibitors in human and mouse lung development. Thrombosis and Haemostasis, (2005) 94(1):175-83.

Li GY, Zhou D, Vicencio A, Ryu J, Xue J, Kannan, A, Gavrialov O and Haddad GG. Effect of carbon dioxide on neonatal mouse lung: a genomic approach. Journal of Applied Physiology, (2005) 101:1556-1564.

Alejandre-Alcazar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG, Tibboel D, Seeger W, Eickelberg O, Morty RE. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Developmental Dynamics, (2008) 237 (1): 259-69.

Douglas R; Ryu J; Kanaan A; Rivero M; Dugan L; Haddad GG; Ali S. Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. American Journal of Physiology - Cell Physiology, (2010) 298: C1594-C1602

Ryu J; Heldt GP; Nguyen M; Gavrialov O; Haddad GG. Chronic hypercapnia alters lung matrix composition in mouse pups. Journal of Applied Physiology, (2010) 109: 203-210.

J. Xue*, P. Zhao*, X.Q. Gu, G.G. Haddad and Y. Xia (2005) “Intermittent Hypoxia Modulates Na+ Channel Expression in Developing Mouse Brain”. International Journal of Developmental Neuroscience, 23(4):327-333. (* equal contribution to this work).

G. Li, D. Zhou, A. G. Vicencio, J. Ryu, J. Xue, A. Kanaan, O. Gavrialov and G. G. Haddad (2006) “Effect of Carbon Dioxide on Neonatal Mouse Lung: A Genomic Approach”. Journal of Applied Physiology.101(6):1556-64.

J. Xue, D. Zhou, H. Yao, O. Gavrialov, M. J. McConnell, B.D. Gelb and G.G. Haddad (2007) “Novel Functional Interaction between Na+/H+ Exchanger 1 and Tyrosine Phosphatase SHP-2”. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292(6):R2406-16.

X.Q. Gu, D. Siemen, S. Parvez, Y. Cheng, J. Xue, D. Zhou, X. Sun, E.A. Jonas and G.G. Haddad (2007) “Hypoxia Increases BK Channel Activity in the Inner Mitochondrial Membrane”. Biochemical and Biophysical Research Communications. 358(1):311-6.

J. Xue, D. Zhou, H. Yao and G.G. Haddad (2007) “Role of Transporters and Ion Channels in Neuronal Injury under Hypoxia”. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 294(2):R451-7.

D. Zhou, J. Xue, J. Chen, P. Morcillo, J.D. Lambert, K.P. White and G.G. Haddad (2007) “Experimental Selection for Drosophila Survival in Extremely Low O2 Environment”. PLoS ONE. 2:e490.

D. Zhou, J. Wang, M. Zapala, J. Xue, N. Schork and G.G. Haddad (2007). “Gene Expression in Mouse Brain Following Chronic Hypoxia: Role of Sarcospan in Glial Cell Death”. Physiological Genomics. 32(3):370-9.

D. Zhou, J. Xue, J.C.K Lai, N.J. Schork, K.P. White and G.G. Haddad (2008). “Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch”. PLoS Genetics. 4(10):e1000221.

J. Xue, F. Mraiche, D. Zhou, M. Karmazyn, T. Oka, L. Fliegel and G.G. Haddad (2010). “Elevated Myocardial Na+/H+ Exchanger Isoform 1 Activity Elicits Gene Expression that Leads to Cardiac Hypertrophy”. Physiological Genomics. 42(3):374-83.

Yao H, Hady Felfly, Juan Wang, Dan Zhou and and Haddad GG: DIDS protects against neuronal injury by blockingToll-like receptor 2 activated-mechanisms. J Neurochem. 2009; 108(3): 835-46.

Sun XL, Yao H, Douglas RM, Gu XQ, Wang J and Haddad GG: Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic slice cultures. J Neurochem. 2010; 112(2): 377-88.

Felfly H, Muotri A, Yao H and Haddad GG: Hematopoietic Stem Cell Transplantation Protects Mice from Lethal Stroke. Exp Neurol.. 2010.

Zhao, H.W., Zhou, D., Nizet, V. & Haddad, G.G. Experimental selection for Drosophila survival in extremely high O2
environments. PLoS One 5, e11701.

Fan C, Iacobas DA, Dan Zhou, Chen Q, Lai JK, Gavrialov O, Haddad GG. Gene Expression and Phenotypic Characterization of Mouse Heart after Chronic Constant or Intermittent Hypoxia. Physiological Genomics 22(3):292-307, 2005.

Sun X, Dan Zhou, Zhang P, Moczydlowski E, Haddad GG. {beta}-Subunit-Dependent Modulation of Hslo BK Current by Arachidonic Acid. J Neurophysiol. 97(1):62-69, 2007.

Sun X, Yao H, Dan Zhou, Gu XQ, Haddad GG. Modulation of hslo BK current inactivation by fatty acid esters of coenzyme A. J Neurochem. 104(5):1394-1403, 2008.

Ruffin VA, Gu XQ, Dan Zhou, Douglas RM, Sun X, Trouth CO, Haddad GG. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Neuroscience. 151(2):410-418, 2008.

Dan Zhou, Visk DW, Haddad GG. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res. 66:239-247, 2009.

Feala JD, Coquin L, Dan Zhou, Haddad GG, Paternostro G, McCulloch AD. Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 3:91, 2009.