About the Zage Lab

Peter E. Zage, MD, PhD

Principal Investigator

Peter E. Zage, MD, PhD is an associate professor-in-residence in pediatric oncology at UC San Diego Moores Cancer Center and attending hematologist/oncologist at Rady Children's Hospital-San Diego. Dr. Zage received his bachelor's degree in biology from The Johns Hopkins University and earned his medical and doctoral degrees from Columbia University in New York. He then completed a residency in pediatrics at the University of Chicago Children's Hospital and a fellowship in pediatric hematology/oncology at Children's Memorial Hospital (now Lurie Children's Hospital) before starting his first faculty position as an assistant professor at the University of Texas MD Anderson Cancer Center. In 2011 he moved to a faculty position in the Section of Pediatric Hematology/Oncology at Baylor College of Medicine and Texas Children's Cancer Center, where he was a member of the Solid Tumor, Neuroblastoma, Retinoblastoma, and Developmental Therapeutics teams, prior to joining the UC San Diego Moores Cancer Center and Rady Children's Hospital in 2016.

Dr. Zage is an expert in the treatment of the pediatric solid tumors neuroblastoma and retinoblastoma, and his laboratory is focused on developing novel treatments and identifying novel targets for therapies for children with solid tumors. His primary laboratory projects include studies to better understand the pathways involved in the regulation of growth factor receptor trafficking and degradation in tumor cells and their role in tumor growth and treatment response in addition to studies to identify novel therapeutic targets and novel agents to use in combination with established therapies.

Dr. Zage's laboratory has identified a key role for the ubiquitin ligase UBE4B in the regulation of receptor trafficking in neuroblastoma tumor cells, and he has also identified several promising novel targeted agents that have been translated into early phase clinical trials for children with relapsed and refractory solid tumors.

Dr. Zage has received an Award of Excellence from the Texas Society of Medical Oncology in 2007 and a Young Investigator Award from the American Society of Pediatric Hematology/Oncology (ASPHO) in 2009 as a result of these projects. He also recently received the Pediatric Investigator Award at the Rady Children's Hospital-San Diego 8th Annual Pediatric Research Symposium in January 2017. Dr. Zage is a member of the American Society of Clinical Oncology, the American Society of Pediatric Hematology/ Oncology, the American Association for Cancer Research, and the Advances in Neuroblastoma Research Association. He is a member of the Children's Oncology Group Neuroblastoma Biology Committee and of the Scientific Committee for the Neuroblastoma-Medulloblastoma Translational Research Consortium. He is currently a member of the UCSD Moores Cancer Center in the Solid Tumor Therapeutics program and of the UCSD Center for Drug Discovery Innovation (CDDI).


Laboratory Personnel

Contact information for our research team members is provided on the Team page. See Contact Us for mailing addresses and telephone numbers for the laboratory.


Open Positions

Postdoctoral Position Available
Postdoctoral Fellowship position available for NIH-funded project to explore the role of UBE4B and growth factor receptor trafficking in pediatric solid tumor pathogenesis. This project explores an emerging area of study in the field with opportunities for mechanistic discovery as well as translational applications.

Requirements: Strong background in cellular and molecular biology required. Prefer experience with in vitro and in vivo models of cancer. English language proficiency and strong publication record preferred.

To Apply: Please send CV and cover letter and contact information for 3 references who are familiar with your scientific work to pzage@ucsd.edu and to c7chang@ucsd.edu. Please indicate specific interest and experience relevant to this position. "Generic" inquiries are not encouraged. To formally apply, please visit the application link for the Postdoctoral Posting.

Funding

Current active funding support for research in the Zage laboratory is provided by:
UCSD Department of Pediatrics start-up funds
The goals of this project are to develop a translational research program devoted to the care of children with neuroblastoma.

NIH R01CA166749-01
"The Role of Growth Factor Receptor Trafficking in Tumorigenesis"

Pedal the Cause Translational Cancer Research Award
"The Role of UBE4B in Neuroblastoma Differentiation"

Bayer Pharma AG
"The Role of RET Inhibition in the Treatment of Neuroblastoma"

UCSD Health Sciences Academic Senate Research Grant

"Novel Cancer Stem Cell-Like Populations in Melanoma"


Clinical and Research Links

Rady Children's Hospital - San Diego UC San Diego School of Medicine