Welcome to the HNRP


HNRP: Performing Cutting-Edge Research on How HIV, Methamphetamine and Other Factors Affect the Nervous System

The mission of the HIV Neurobehavioral Research Program (HNRP) is to initiate and promote translational NeuroAIDS research through the development, coordination and realization of multi-disciplinary studies.


HIV Neurobehavioral Research Center (HNRC)

The mission of the HIV Neurobehavioral Research Center (HNRC) is to increase our understanding of how HIV and other diseases affect the human nervous system. The Center is supported by public funding from the National Institutes of Health (NIH), the State of California, and other sources (NIMH/CSPAR Award Number P30MH062512). The HNRC conducts local, national, and international research devoted to advancing our knowledge of the prevention, diagnosis and treatment of HIV-related diseases as they affect the brain and nervous system, and result in impairment of everyday functioning.

Translational Methamphetamine AIDS Research Center (TMARC)

The Translational Methamphetamine AIDS Research Center (TMARC) is supported by public funding from the National Institutes of Health (NIH) and National Insititute on Drug Abuse (NIDA) (NIH/NIDA Award Number P50DA026306) to provide scientific leadership, technical support, and opportunities for training to coalesce the efforts of an interdisciplinary group of investigators to elucidate the combined effects of methamphetamine and HIV infection on the central nervous system.

CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER)

The CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study was first funded in September 2002 in response to NIMH RFA 00-AI-0005 to explore the changing presentation of HIV neurological complications in the context of emerging antiviral treatments such as highly active antiretroviral therapy (HAART). Current public funding includes grants from the National Institute of Health (NIH), the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) via the CHARTER Extension (NIH/NIMH/NINDS Award Number HHSN271201000036C) and CHARTER as a Resource (NIH/NIMH/NINDS Award Number HHSN271201000030C). CHARTER’s study aims are to determine how central and peripheral nervous system complications of HIV are affected by different histories and regimens of antiretroviral therapy (ART). Participants receive comprehensive neuromedical, neurocognitive, and laboratory examinations, with a subset undergoing host/viral genetic characterization and neuroimaging. In order to have a broad representation of participant characteristics, CHARTER is conducted at six performance sites nationally whose activities are coordinated by UCSD, the principal grantee institution, which includes several technical, scientific, and administrative components to guide the work.

California NeuroAIDS Tissue Network (CNTN)

The California NeuroAIDS Tissue Network (CNTN) is a research resource based at the University of California, San Diego, sponsored by the U.S. National Institute of Mental health (NIMH) and the National Institutes of Health (NIH) (NIMH/NIH Award Number U24 MH100928). CNTN acquires and makes available well-characterized tissues from individuals who have Central Nervous System involvement with Human Immunodeficiency Virus (HIV).